Ex26
Based on 1 publication(s) in Google Scholar
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach.
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- Pureté : 99%
- CAS No.: 1233332-37-0
- Formule: C28H28ClFN2O3
- Masse moléculaire:494.98
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Ex26
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Activité biologique
Description
IC50 & Target
IC50: 0.93 nM (S1P1)[1]
In Vitro
Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells, and Chinese hamster ovary cells
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Concentration:0-10 μM
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Incubation Time:1 hour
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Result:Confirmed a potent and selective antagonist of S1P1 (IC50=0.93 nM).
In Vivo
Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old male C57Bl/6J mice[1]
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Dosage:3 mg/kg
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Administration:Intraperitoneal injection; 3 mg/kg; once daily; 3 days
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Result:Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen.
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Animal Model:Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis[1]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection; 30 mg/kg; once daily; 15 days
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Result:Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment.
Chemical Information
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CAS No. 1233332-37-0
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Appearance Solid
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Masse moléculaire 494.98
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Formule C28H28ClFN2O3
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Color White to off-white
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SMILES
O=C(O)C1(CC1)NC(C2=C(C=C(C=C2C)C3=CC(NC(C)C4=CC=C(C(C)=C4)Cl)=CC=C3F)C)=O
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Synonyms
S1P1-IN-Ex26
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Naunyn Schmiedebergs Arch Pharmacol
Label-free cell phenotypic profiling of sphingosine-1-phosphate receptor 1 and discovery of its agonist from natural products. [Abstract]2026 May 29. PMID: 42209736
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ex26 Related Classifications
HY-117213 Related Classifications
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