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Cat. No.: HY-184083

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Fenharmane

Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle.

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CAS No.: 3851-30-7
Formule: C₁₈H₁₈N₂
Masse moléculaire:262.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fenharmane Chemical Structure

CAS No.: 3851-30-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle^[1].

IC₅₀ & Target

^[1]

5HT2B

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	27.4 μM Compound: 66	Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay	[PMID: 34479038]

In Vitro

Fenharmane (compound19) exhibits antagonistic activity against 5-HT-induced contractile responses in isolated fundus smooth muscle tissues of rats, with a negative logarithm of the apparent dissociation constant (-log K_B) of 7.61^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 3851-30-7
Masse moléculaire 262.35
Formule C₁₈H₁₈N₂
SMILES

C1(CC2NCCC3=C2NC4=C3C=CC=C4)=CC=CC=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Audia JE, et al. Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. J Med Chem. 1996 Jul 5;39(14):2773-80. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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