TOB1 - transducer of ERBB2, 1 Gene

Also Known as TOB; TROB; APRO5; APRO6; PIG49; TROB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10140

About TOB1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,862,223-50,867,978 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues.

Summary

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

TOB1 Products (3)

mRNA Protein Name
NM_001243877.2 NP_001230806.1 protein Tob1 isoform 1
NM_001243885.2 NP_001230814.1 protein Tob1 isoform 2
NM_005749.4 NP_005740.1 protein Tob1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
18377426 GOA
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
8632892 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
8632892 GOA
involved in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
18377426 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
23236473 GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
21336257 GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
21336257 GOA
Cellular Component GO Annotation Evidence Références Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
21336257 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOB1 Protein Structure

BTG

BTG: BTG family (1 - 114)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

protein Tob1

  • proliferation-inducing gene 49

TOB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TOB1 P50616 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
18377426
Intra
TOB1 P50616 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
28514442
Intra
TOB1 P50616 CNOT10 Homo sapiens Q9H9A5
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
18377426
Intra
TOB1 P50616 TNKS1BP1 Homo sapiens Q9C0C2
Anti Tag CoIP
33961781
Intra
TOB1 P50616 TNKS1BP1 Homo sapiens Q9C0C2
Anti Tag CoIP
28514442
Intra
TOB1 P50616 CNOT7 Homo sapiens Q9UIV1
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT7 Homo sapiens Q9UIV1
GMS
19276069
Intra
TOB1 P50616 CNOT7 Homo sapiens Q9UIV1
Pull Down
19276069
Intra
TOB1 P50616 CNOT7 Homo sapiens Q9UIV1
Y2H Array
31515488
Intra
TOB1 P50616 RAVER1 Homo sapiens Q8IY67
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CPEB4 Homo sapiens Q17RY0
Anti Tag CoIP
21336257
Intra
TOB1 P50616 CPEB4 Homo sapiens Q17RY0
Pull Down
21336257
Intra
TOB1 P50616 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
TOB1 P50616 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
TOB1 P50616 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
TOB1 P50616 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
TOB1 P50616 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
TOB1 P50616 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
TOB1 P50616 CNOT9 Homo sapiens Q92600
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT9 Homo sapiens Q92600
Anti Tag CoIP
28514442
Intra
TOB1 P50616 CNOT9 Homo sapiens Q92600
TAP
18377426
Intra
TOB1 P50616 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
TOB1 P50616 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
TOB1 P50616 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
TOB1 P50616 CNOT2 Homo sapiens Q9NZN8
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT3 Homo sapiens O75175
Anti Tag CoIP
33961781
Intra
TOB1 P50616 CNOT3 Homo sapiens O75175
Anti Tag CoIP
28514442
Intra
TOB1 P50616 PABPC1 Homo sapiens P11940
ITC
20595394
Intra
TOB1 P50616 PABPC1 Homo sapiens P11940
NMR
20595394
Intra
TOB1 P50616 CPEB3 Homo sapiens Q8NE35
Pull Down
21336257
Intra
TOB1 P50616 CPEB3 Homo sapiens Q8NE35
Anti Tag CoIP
21336257
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14872 TOB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TOB1 VGNC VGNC:78613
Mus musculus TOB1 MGD MGI:1349721
Felis catus TOB1 VGNC VGNC:82316
Bos taurus TOB1 VGNC VGNC:36212
Canis familiaris TOB1 VGNC VGNC:49663
Rattus norvegicus TOB1 RGD RGD:621126
Others TOB1 NCBI