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INPP5J - inositol polyphosphate-5-phosphatase J Gene

Also Known as PIPP; INPP5; PIB5PA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27124

About INPP5J

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,122,923-31,134,697 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 13 paralogues. Biased expression in thyroid (RPKM 63.8), small intestine (RPKM 7.6) and 4 other tissues.

Summary

Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

INPP5J Products (6)

mRNA	Protein	Name
NM_001002837.2	NP_001002837.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c
NM_001284285.2	NP_001271214.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a
NM_001284286.1	NP_001271215.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b
NM_001284287.1	NP_001271216.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform d
NM_001284288.1	NP_001271217.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e
NM_001284289.1	NP_001271218.1	phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12536145	GOA
located in ruffle	IDA IDA: Inferred from direct assay	12536145	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5J Protein Structure

Exo_endo_phos

0
200
400
600
800
1006 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

INPP5J Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	INPP5J	Q15735	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	INPP5J	Q15735	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	INPP5J	Q15735	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	INPP5J	Q15735	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	INPP5J	Q15735	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	INPP5J	Q15735	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	INPP5J	Q15735	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	INPP5J	Q15735	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	INPP5J	Q15735	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	INPP5J	Q15735	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	INPP5J	Q15735	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	INPP5J	Q15735	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	INPP5J	Q15735	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	INPP5J	Q15735	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	INPP5J	Q15735	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	25416956
Intra	INPP5J	Q15735	PELI1	Homo sapiens	Q96FA3	Validated Y2H	32296183
Intra	INPP5J	Q15735	PELI1	Homo sapiens	Q96FA3	Y2H Array	32296183
Intra	INPP5J	Q15735	PELI1	Homo sapiens	Q96FA3	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	INPP5J	Q15735	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	INPP5J	Q15735	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	INPP5J	Q15735	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
Intra	INPP5J	Q15735	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	INPP5J	Q15735	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	INPP5J	Q15735	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	INPP5J	Q15735	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	INPP5J	Q15735	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	INPP5J	Q15735	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	INPP5J	Q15735	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lowe Oculocerebrorenal Syndrome	Lowe Syndrome Oculocerebrorenal Syndrome OCRL Oculocerebrorenal Syndrome Of Lowe Ocrl1 Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency Lowe Disease Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency Cerebrooculorenal Syndrome Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency Lowe Oculo-Cerebro-Renal Dystrophy Lowe Oculo-Cerebro-Renal Syndrome Lowe Oculocerebrorenal Dystrophy Low Chromosome 11p Deletion Syndrome Oculocerebrorenal Dystrophy Cerebro-Oculorenal Dystrophy Ocrl1 - [Oculocerebrorenal Syndrome] Lowe-Terrey-Maclachlan Syndrome Renal-Oculocerebrodystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS06832	INPP5J Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INPP5J	VGNC	VGNC:53909
Felis catus	INPP5J	VGNC	VGNC:68841
Canis familiaris	INPP5J	VGNC	VGNC:42035
Macaca mulatta	INPP5J	VGNC	VGNC:73814
Rattus norvegicus	INPP5J	RGD	RGD:620541
Mus musculus	INPP5J	MGD	MGI:2158663
Others	INPP5J	NCBI