GP2 - glycoprotein 2 Gene

Also Known as ZAP75

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2813

About GP2

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,309,574-20,327,513 (from NCBI)

This gene has 11 transcripts (splice variants), 374 orthologues and 5 paralogues. Restricted expression toward pancreas (RPKM 2558.6).

Summary

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GP2 Products (4)

mRNA Protein Name
NM_001007240.3 NP_001007241.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein
NM_001007241.3 NP_001007242.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 3 precursor
NM_001007242.3 NP_001007243.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 4 precursor
NM_001502.4 NP_001493.2 pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables antigen binding IDA
IDA: Inferred from direct assay
19907495 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Références Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19907495 GOA
located in endosome IDA
IDA: Inferred from direct assay
19907495 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GP2 Protein Structure

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (229 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
Protein Preferred Names Protein Names

pancreatic secretory granule membrane major glycoprotein GP2

  • glycoprotein 2 (zymogen granule membrane)

Related Diseases

Diseases Alias
Argentine Hemorrhagic Fever

  • Argentinian Hemorrhagic Fever

  • Junin Hemorrhagic Fever

  • Hemorrhagic Fever, Argentinian

  • Ahf - [Argentinian Haemorrhagic Fever]

  • Argentine Haemorrhagic Fever

  • Junin Haemorrhagic Fever
Bolivian Hemorrhagic Fever

  • Machupo Hemorrhagic Fever

  • Hemorrhagic Fever, Bolivian

  • Bhf - [Bolivian Haemorrhagic Fever]

  • Machupo Haemorrhagic Fever
Venezuelan Hemorrhagic Fever

  • Guanarito Hemorrhagic Fever

  • Vehf - [Venezuelan Haemorrhagic Fever]
Marburg Hemorrhagic Fever

  • Marburg Virus Disease

  • Marburg Disease

  • Green Monkey Disease

  • Mhf

  • Vervet Monkey Disease

  • Mard - [Marburg Disease]

  • Mvd - [Marburg Virus Disease]

  • Marburg Haemorrhagic Fever

  • Mhf - [Marburg Haemorrhagic Fever]
Inflammatory Bowel Disease 29

  • IBD29

  • {Inflammatory Bowel Disease 29}
Brazilian Hemorrhagic Fever

  • Sabia Hemorrhagic Fever
Ebola Hemorrhagic Fever

  • Ebola Virus Disease

  • Viral Hemorrhagic Fever

  • Hemorrhagic Fever, Ebola

  • Ebola

  • Ehf

  • Ebola Fever

  • Hemorrhagic Fevers, Viral

  • Ebola Haemorrhagic Fever

  • Ebod - [Ebola Disease]

  • Evd - [Ebola Virus Disease]

  • Ebola Virus Haemorrhagic Fever

  • Vhf - [Viral Haemorrhagic Fever] Nos

  • Viral Haemorrhagic Fever, Not Otherwise Specified
Lassa Fever

  • Lf

  • Lassa Hemorrhagic Fever

  • Lf - [Lassa Fever]
Lujo Hemorrhagic Fever

  • Zambian Hemorrhagic Fever
Foodborne Botulism

  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos
Acute Pancreatitis

  • Pancreatitis

  • Pancreatitis, Acute Necrotizing

  • Pancreatitis Nos

  • Acute Pancreas Inflammation
Blessig'S Cysts

  • Microcystoid Retinal Degeneration

  • Blessig Cysts

  • Iwanoff'S Cysts

  • Microcystoid Degeneration Of Retina
De Quervain Disease

  • Radial Styloid Tenosynovitis

  • Tenosynovitis, De Quervain'S

  • De Quervain'S Disease

  • Tenosynovitis Of Radial Styloid Process

  • Stenosans Tenosynovitis
Intestinal Tuberculosis

  • Tuberculosis Of Intestine

  • Tuberculosis Of Intestines
Bagassosis

  • Sugar Cane Worker Pneumonitis

  • Bagasse Workers' Lung

  • Bagasse Disease

  • Bagasse Disease Or Pneumonitis

  • Bagasse Workers' Disease

  • Fibrosis Of Lung With Bagassosis

  • Sugar Cane Workers' Hypersensitivity Pneumonitis

  • Bagasse Pneumonitis

  • Hypersensitivity Pneumonitis With Bagassosis
Gastrointestinal Tuberculosis

  • Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands

  • Tuberculosis, Gastrointestinal

  • Tuberculosis Of Gastrointestinal Tract

  • Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands
Stuttering

  • Stammering

  • Familial Persistent Stuttering

  • Stuttering, Familial Persistent 1
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-173637 AZD0022 Inhibitor 98.36% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-159857 Gp(2′-5′)Ap sodium 98.88% Unkown
HY-147089 PRRSV/CD163-IN-1 Inhibitor 98.28% Unkown
HY-173637A (S)-AZD0022 Inhibitor 95.16% Unkown
HY-P1855 HER2/neu (654-662) GP2 98.26% Unkown
HY-107471 CB2 receptor agonist 3 Agonist 99.84% Unkown
HY-RS05609 GP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1135843 ARN-75039 Inhibitor / Unkown
HY-RS17869 Gp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-17367S2 Atazanavir-d9 / Unkown
HY-17367S3 Atazanavir-d5 / Unkown
HY-173329 KRAS-IN-41 Inhibitor / Unkown
HY-17367S4 Atazanavir-d6 99.28% Unkown
HY-179484 KRASG12C IN-19 Inhibitor / Unkown
HY-180885S KRAS G12D-IN-35 Inhibitor / Unkown
HY-P5695 GP-2B Inhibitor / Unkown
HY-109671 2-Amino-N-hydroxybenzamide / Unkown
HY-RS24338 Gp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00191 GP2-114 / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P991450 ADI-15878 Inhibitor 99.80% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GP2 RGD RGD:621695
Macaca mulatta GP2 VGNC VGNC:73114
Mus musculus GP2 MGD MGI:1914383
Bos taurus GP2 VGNC VGNC:29505
Canis familiaris GP2 VGNC VGNC:41356
Felis catus GP2 VGNC VGNC:80577
Others GP2 NCBI