USP4 - ubiquitin specific peptidase 4 Gene

Also Known as UNP; Unph

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7375

About USP4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,277,144-49,340,053 (from NCBI)

This gene has 14 transcripts (splice variants), 140 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 15.1), bone marrow (RPKM 14.6) and 25 other tissues.

Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP4 Products (3)

mRNA Protein Name
NM_001251877.2 NP_001238806.1 ubiquitin carboxyl-terminal hydrolase 4 isoform c
NM_003363.4 NP_003354.2 ubiquitin carboxyl-terminal hydrolase 4 isoform a
NM_199443.3 NP_955475.1 ubiquitin carboxyl-terminal hydrolase 4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables adenosine receptor binding IPI
IPI: Inferred from physical interaction
16339847 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
16316627 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22001210 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11461834 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
16472766 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
30514904 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
16316627 GOA
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
20595234 GOA
involved in protein localization to cell surface IDA
IDA: Inferred from direct assay
16339847 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
16472766 GOA
involved in spliceosomal tri-snRNP complex assembly IMP
IMP: Inferred from mutant phenotype
20595234 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16316627 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16339847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP4 Protein Structure

DUSP

DUSP: DUSP domain (31 - 122)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (140 - 226)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (301 - 920)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 4

  • deubiquitinating enzyme 4

USP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
USP4 Q13107 ADORA2A Homo sapiens P29274
Anti Tag CoIP
16339847
Intra
USP4 Q13107 RIPK1 Homo sapiens Q13546
Anti Bait CoIP
23313255
Intra
USP4 Q13107 RIPK1 Homo sapiens Q13546
Anti Tag CoIP
23313255
Intra
USP4 Q13107 HUWE1 Homo sapiens Q7Z6Z7
Anti Bait CoIP
21522127
Intra
USP4 Q13107 MEPCE Homo sapiens Q7L2J0
Anti Tag CoIP
33961781
Intra
USP4 Q13107 EDC3 Homo sapiens Q96F86
Anti Tag CoIP
19615732
Intra
USP4 Q13107 USP4 Homo sapiens Q13107
GMS
22001210
Intra
USP4 Q13107 EDC3 Homo sapiens Q96F86
Anti Tag CoIP
33961781
Intra
USP4 Q13107 PRPF3 Homo sapiens O43395
Anti Tag CoIP
19615732
Intra
USP4 Q13107 TUT1 Homo sapiens Q9H6E5
Anti Tag CoIP
19615732
Intra
USP4 Q13107 PRPF4 Homo sapiens O43172
Anti Tag CoIP
19615732
Intra
USP4 Q13107 USP4 Homo sapiens Q13107
NMR
22001210
Intra
USP4 Q13107 DCP1B Homo sapiens Q8IZD4
Anti Tag CoIP
33961781
Intra
USP4 Q13107 MEPCE Homo sapiens Q7L2J0
Anti Tag CoIP
19615732
Intra
USP4 Q13107 PRPF3 Homo sapiens O43395
Anti Tag CoIP
33961781
Intra
USP4 Q13107 TUT1 Homo sapiens Q9H6E5
Anti Tag CoIP
33961781
Intra
USP4 Q13107 PRPF4 Homo sapiens O43172
Anti Tag CoIP
33961781
Intra
USP4 Q13107 USP11 Homo sapiens P51784
Anti Tag CoIP
33961781
Intra
USP4 Q13107 DCP1B Homo sapiens Q8IZD4
Anti Tag CoIP
19615732
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Trichorhinophalangeal Syndrome, Type I

  • Trichorhinophalangeal Dysplasia Type I

  • TRPS1

  • Trichorhinophalangeal Syndrome Type I

  • Trps I

  • Trichorhinophalangeal Syndrome Type 1

  • Type I Trichorhinophalangeal Syndrome

  • Giedion Syndrome

  • Trp Syndrome

  • Tricho-Rhino-Phalangeal Syndrome 1

  • Trichorhinophalangeal Syndrome, Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-180171 USP11-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP4 VGNC VGNC:66886
Bos taurus USP4 VGNC VGNC:36729
Macaca mulatta USP4 VGNC VGNC:78416
Rattus norvegicus USP4 RGD RGD:1587387
Mus musculus USP4 MGD MGI:98905
Canis familiaris USP4 VGNC VGNC:48195
Others USP4 NCBI