GrTx1
GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively. GrTx1 can be used for neurological disease research.
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- Formule: C159H243N45O41S8
- Masse moléculaire:3697.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
GrTx1 (0-100 μΜ, 3 min) blocks Na+ currents of neuroblastoma F-11 cells with an IC50 of 2.8 μM[1]. GrTx1 (10 μΜ, 3 min) blocks about 85% Na+ currents of neuroblastoma F-11 cells with no effects on common K+ channels, such as Kv1.1 and 1.4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 3697.43
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Formule C159H243N45O41S8
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Sequence
Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Lys-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Gln-Leu-Trp-Cys-Lys-Lys-Arg-Leu (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25)
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Sequence Shortening
YCQKWMWTCDSKRKCCEDMVCQLWCKKRL (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25)
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Initial Source
Grammostola rosea
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Clement H,et.al. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels. Toxicon. 2007 Jul;50(1):65-74. [Content Brief]
[2]. Redaelli E, et.al. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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