Herbacitrin
Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC50 values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection.
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- CAS No.: 35815-07-7
- Formule: C21H20O12
- Masse moléculaire:464.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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HIV-1 |
Herbacitrin (4 days) exhibits dose-dependent cytotoxicity toward MT-4 and MT-2 human T-cell lines, with CC50 values of 27.8 μM and 63.64 μM, respectively[1].
Herbacitrin (2.1 μM; 5 days) significantly inhibits HIV-1 replication in HIV-1-infected MT-4 and MT-2 human T-cell lines, as measured by reduced p24 core protein levels[1].
Herbacitrin (2.15-21.5 μM) significantly inhibits recombinant HIV-1 reverse transcriptase activity at 21.5 μM, but not at 2.15 μM[1].
Herbacitrin (2.15-21.5 μM) significantly inhibits recombinant HIV-1 integrase activity at both 2.15 μM and 21.5 μM, with greater potency at the higher concentration[1].
Herbacitrin (10-50 μM; 6 days) dose-dependently inhibits the growth of normal Balb/c-derived SFME cells, shows biphasic stimulatory/inhibitory effects on ras-transformed Balb/c-derived SFME cells, and exerts only weak growth inhibition on ras/myc-transformed Balb/c-derived SFME cells, with complete inhibition of normal cells occurring at 40-50 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HIV-1-infected MT-4, MT-2 human T-cell lines
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Concentration:2.1 μM
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Incubation Time:5 days
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Result:Reduced HIV-1 replication in both MT-4 and MT-2 cells, as shown by decreased p24 core protein levels, and exhibited statistically significant differences compared with the negative control.
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Cell Line:normal serum-free mouse embryo (SFME) cells, ras-transformed SFME cells, ras/myc-transformed SFME cells (all derived from Balb/c mouse embryonic cells)
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Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM
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Incubation Time:6 days
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Result:Markedly inhibited normal SFME cell growth dose-dependently, induced biphasic growth regulation in ras-transformed SFME cells, and weakly suppressed ras/myc-transformed SFME cell proliferation.
Chemical Information
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CAS No. 35815-07-7
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Masse moléculaire 464.38
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Formule C21H20O12
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SMILES
OC1=C2C(C(C(O)=C(C3=CC=C(C=C3)O)O2)=O)=C(C=C1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Herbacitrin Related Classifications
HY-N15438 Related Classifications
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