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Cat. No.: HY-136392

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IKK-IN-3

IKK-IN-3 is a potent and selective IkappaB kinase 2 (IKK2 or IKKβ) inhibitor, with IC₅₀s of 19 and 400 nM for IKK2 and IKK1 (or IKKα), respectively.

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CAS No.: 615528-53-5
Formule: C₁₇H₁₇N₅S
Masse moléculaire:323.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

IKK-IN-3 Chemical Structure

CAS No.: 615528-53-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IKK-IN-3 is a potent and selective IkappaB kinase 2 (IKK2 or IKKβ) inhibitor, with IC₅₀s of 19 and 400 nM for IKK2 and IKK1 (or IKKα), respectively^[1].

Voir tous les produits spécifiques à Isoform IKK :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	CC₅₀	77 μM Compound: 13b	Cytotoxicity against Jurkat cells by Alamar blue assay Cytotoxicity against Jurkat cells by Alamar blue assay	[PMID: 17540562]
Jurkat	EC₅₀	>100 μM Compound: 13b	Inhibition of LPS-induced TNFalpha production in Jurkat cells Inhibition of LPS-induced TNFalpha production in Jurkat cells	[PMID: 17540562]

Chemical Information

CAS No. 615528-53-5
Masse moléculaire 323.42
Formule C₁₇H₁₇N₅S
SMILES

NCCNC1=NC(C=C(C2=CC=CC=C2)S3)=C3N4C1=NC=C4C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kempson J , et al. Novel tricyclic inhibitors of IkappaB kinase. J Med Chem. 2009;52(7):1994‐2005. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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IKK-IN-3

Voir tous les produits spécifiques à Isoform IKK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

IKK-IN-3 Related Classifications

HY-136392 Related Classifications