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Cat. No.: HY-169634

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JD118

Name: JD118
Brand: MedChemExpress
SKU: HY-169634
Price: 137.00 USD
Availability: InStock
Rating: 5 (1 reviews)

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135).

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CAS No.: 315704-83-7
Formule: C₁₃H₁₂N₄S₂
Masse moléculaire:288.39

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JD118 Chemical Structure

CAS No.: 315704-83-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135)^[1].

Voir tous les produits spécifiques à Isoform JNK :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	44 μM Compound: 7	Antiproliferative activity against MCF7 cells after 72 hrs Antiproliferative activity against MCF7 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	55 μM Compound: 7	Antiproliferative activity against SkBr3 cells after 72 hrs Antiproliferative activity against SkBr3 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	61 μM Compound: 7	Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA	[PMID: 17223347]

Chemical Information

CAS No. 315704-83-7
Masse moléculaire 288.39
Formule C₁₃H₁₂N₄S₂
SMILES

CC1=C(SC(N)=N1)C2=CSC(NC3=CC=CC=C3)=N2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ngoei KR, et al. Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochim Biophys Acta. 2013;1834(6):1077-1088. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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