Kurarinol
Based on 1 publication(s) in Google Scholar
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase.
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- CAS No.: 855746-98-4
- Formule: C26H32O7
- Masse moléculaire:456.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Kurarinol
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Activité biologique
Description
IC50 & Target
IC50: 0.1 μM (mushroom tyrosinase)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
44 μg/mL
Compound: Kurarinol
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Antiviral activity against HSV2 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
Antiviral activity against HSV2 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
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[PMID: 9868163] |
| Vero | EC50 |
60 μg/mL
Compound: Kurarinol
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Antiviral activity against HSV1 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
Antiviral activity against HSV1 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
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[PMID: 9868163] |
In Vitro
Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1].
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1].
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3]
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Dosage:20 mg/kg
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Administration:Oral administration, daily, for 3 days
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Result:Decreased serum TC, TG, and LDL-C levels.
Chemical Information
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CAS No. 855746-98-4
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Masse moléculaire 456.53
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Formule C26H32O7
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SMILES
CC([C@H](CCC(C)(O)C)CC(C(O)=C1)=C(O[C@H](C(C=CC(O)=C2)=C2O)CC3=O)C3=C1OC)=C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Références
[1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8. [Content Brief]
[2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65. [Content Brief]
[3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kurarinol Related Classifications
HY-122933 Related Classifications
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