Luffariellolide
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear).
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- CAS No.: 111149-87-2
- Formule: C25H38O3
- Masse moléculaire:386.57
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Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L5178Y | ED50 |
3.3 μg/mL
Compound: 6
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Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
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[PMID: 15568767] |
| MDA-MB-231 | IC50 |
4.5 μM
Compound: 11
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
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[PMID: 23944963] |
| T47D | IC50 |
3.6 μM
Compound: 11
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Inhibition of hypoxia-induced HIF-1 activation in human T47D cells by luciferase reporter gene assay
Inhibition of hypoxia-induced HIF-1 activation in human T47D cells by luciferase reporter gene assay
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[PMID: 23944963] |
| T47D | IC50 |
5.1 μM
Compound: 11
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Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
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[PMID: 23944963] |
Chemical Information
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CAS No. 111149-87-2
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Appearance Oil
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Masse moléculaire 386.57
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Formule C25H38O3
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Color Off-white to light yellow
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SMILES
CC1(CCCC(C)=C1CC/C(C)=C/CC/C(C)=C/CCC2=CC(OC2O)=O)C
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Structure Classification
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Initial Source
Palauan sponge
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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TPA/Croton Oil Ear Edema and Dermatitis
The TPA (12-O-tetradecanoylphorbol-13-acetate) and croton oil-induced mouse ear edema model is a well-established acute cutaneous inflammation system used to evaluate topical anti-inflammatory activity by measuring edema formation, neutrophil infiltration, vascular permeability, and cytokine-mediated skin responses in vivo. The inflammatory response is triggered by topical application of phorbol esters (TPA) or croton oil constituents, leading to rapid activation of protein kinase C signaling, leukocyte recruitment, and increased vascular permeability, which can be quantified by ear thickness, weight, dye extravasation, and biochemical markers such as myeloperoxidase (MPO) activity and pro-inflammatory mediators in ear tissue homogenates. This model is widely used for screening anti-inflammatory agents, where reductions in edema and inflammatory biomarkers reflect suppression of acute dermal inflammation and immune cell infiltration. Histological evaluation typically confirms epidermal
Pureté et documentation
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Fiche technique (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Luffariellolide Related Classifications
HY-118725 Related Classifications
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