Manoalogue
Manoalogue is an irreversible secretory phospholipase A2 (sPLA2) inhibitor. Manoalogue covalently modifies K94 of bee venom phospholipase A2 (bvPLA2) to inactivate the enzyme and shows selective inhibition on bvPLA2. Manoalogue can suppress PLA2-mediated contractions of guinea pig lung pleural strips. Manoalogue is used for sPLA2 mechanism and respiratory physiology research.
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- CAS No.: 136440-42-1
- Formule: C19H26O4
- Masse moléculaire:318.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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sPLA2 |
Manoalogue (manoalogue/bvPLA2 mole ratio of 20; 20-120 min) inactivates wild-type bvPLA2 and most lysine-to-glutamate bvPLA2 mutants by covalent modification of lysine 94 (K94), while the K94E mutant is fully resistant to this inactivation, and the K85E mutant shows slight resistance[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 136440-42-1
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Masse moléculaire 318.41
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Formule C19H26O4
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SMILES
C/C(C)=C/CC/C(C)=C/C/C(C=O)=C\CCC(C(O1)O)=CC1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Snyder DW, et al. Evidence that phospholipase A2 (PLA2) inhibitors can selectively block PLA2-mediated contractions of guinea pig lung pleural strips. J Pharmacol Exp Ther. 1992;262(3):1147-1153. [Content Brief]
[2]. Ghomashchi F, et al. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis. Biochemistry. 1998;37(19):6697-6710. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Manoalogue Related Classifications
HY-182680 Related Classifications
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