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Cat. No.: HY-N21574

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Milliamine D

Milliamine D is a diterpenoid toxin of the ingenol ester class containing an anthraniloyl tripeptide, existing in the free base form and exhibiting molluscicidal activity. Milliamine D can be used in the study of schistosomiasis.

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CAS No.: 88524-59-8
Formule: C₄₅H₄₉N₃O₁₀
Masse moléculaire:791.88

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Milliamine D Chemical Structure

CAS No.: 88524-59-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Parasite :

In Vitro

Milliamine D (compound 7) (100 μg/L; 24 h) kills 100% of Biomphalaria glabrata snails^[2].
Milliamine D is a 5,20-diester of ingenol, featuring an anthraniloyl tripeptide side chain with a terminal N,N-dimethylamino group and an acetyl group at position 20^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Milliamine D (0.18 nmol; topical application; single administration) induces ear irritation in mice, with an ID₅₀²⁴of 0.18 nmol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI (ear irritation assay; tumour promotion tests strain)^[1]
Dosage:

0.18 nmol
Administration:

topical; single application
Result:

Was determined to have a 24-hour irritant dose 50 of 0.18 nmol for ear irritation.
Exhibited an irritancy (I²⁴ = 1/ID₅₀²⁴) of 5.6 nmol^-1.

Chemical Information

CAS No. 88524-59-8
Masse moléculaire 791.88
Formule C₄₅H₄₉N₃O₁₀
SMILES

O=C(O[C@@H]1C(COC(C)=O)=C[C@](C2=O)([H])[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@]42[C@]1(O)[C@@H](O)C(C)=C4)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Marston A, et al. On the Active Principles of the Euphorbiaceae VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii. Planta Med,1983,47(3):141-147.

[2]. Carlos Leomar Zani, et al. Molluscicidal milliamines from Euphorbia milii var. hislopii, Phytochemistry,
Volume 34, Issue 1, 1993, Pages 89-95, ISSN 0031-9422.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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