ML169
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.
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- CAS No.: 1222878-02-5
- Formule: C21H17BrFN3O4S
- Masse moléculaire:506.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
EC50: 1.38 µM (M1 mAChR)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1.38 μM
Compound: 15j, VU0405652, ML169
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Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
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[PMID: 21194936] |
In Vitro
ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5[1].
ML169 shifts APP processing towards a non-amyloidogenic pathway[1].
ML169 (2 µM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 µM CCh[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1222878-02-5
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Masse moléculaire 506.34
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Formule C21H17BrFN3O4S
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SMILES
O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4
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Synonyms
VU0405652
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML169 Related Classifications
HY-120576 Related Classifications
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