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NDNA4

NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC50: 0.34 μM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC50 >100 μM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins.

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  • Formule: C31H35F3N2O5S
  • Masse moléculaire:604.68
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • NDNA4 Chemical Structure
    NDNA4 Chemical Structure
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  • NDNA4 Chemical Structure
    NDNA4 Chemical Structure
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  • NDNA4