O-7460
Based on 1 Customer Validation
O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels.
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- Pureté: 95.0%
- CAS No.: 1572051-31-0
- Formule: C25H48FO5P
- Masse moléculaire:478.62
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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DAGLα |
O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet[1]
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Dosage:6, 12 mg/kg
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Administration:A single i.p.
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Result:Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.
The highest dose significantly counteracted the body weight increase.
Chemical Information
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CAS No. 1572051-31-0
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Appearance Liquid
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Masse moléculaire 478.62
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Formule C25H48FO5P
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Color Colorless to light yellow
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SMILES
CC(OCC(COP(F)(C)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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