Ru-Poma
Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively.
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- Formule: C89H75Cl2N11O11Ru.7H2O
- Masse moléculaire:1664.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cereblon |
Chemical Information
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Masse moléculaire 1664.61
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Formule C89H75Cl2N11O11Ru.7H2O
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SMILES
O=C1N(C(C2=C1C(NCCCOC3=CC=C(C4=NC5=C(C6=CC=C[N]7=C6C8=C5C=CC=[N]8[Ru+2]79([N]%10=CC=C(C(C=C%11)=C%10%12)C%13=CC=CC=C%13)([N]%14=CC=C(C%15=C%14C%16=[N]9C=CC(C%17=CC=CC=C%17)=C%16C=C%15)C%18=CC=CC=C%18)[N]%19=C%12C%11=C(C=C%19)C%20=CC=CC=C%20)N4C%21=CC=CC=C%21)C=C3)=CC=C2)=O)C%22CCC(NC%22=O)=O.O.O.O.O.O.O.[Cl-].[Cl-].O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ru-Poma Related Classifications
HY-161668 Related Classifications
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