Cat. No.: HY-145010

SN-011

15 Cited Publications

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Based on 15 publication(s) in Google Scholar

SN-011 is a potent and selective mouse and human STING inhibitor, with an IC₅₀ of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease.

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Pureté: 99.94%
CAS No.: 2249435-90-1
Formule: C₂₅H₁₉FN₂O₄S
Masse moléculaire:462.49

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

SN-011 Chemical Structure

CAS No.: 2249435-90-1

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (15)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC50: 76 nM (STING signaling)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	138 μM Compound: 20; SN-011	Cytotoxicity against mouse BMDM cells assessed as cell viability Cytotoxicity against mouse BMDM cells assessed as cell viability	[PMID: 35635952]
HFF	IC₅₀	107.1 μM Compound: 20; SN-011	Cytotoxicity against HFF cells assessed as cell viability Cytotoxicity against HFF cells assessed as cell viability	[PMID: 35635952]
MEF	IC₅₀	127.5 μM Compound: 20; SN-011	Cytotoxicity against MEF cells assessed as cell viability Cytotoxicity against MEF cells assessed as cell viability	[PMID: 35635952]

In Vitro

SN-011 (1 μM; pretreated for 6 h) significantly suppresses the STING stimulator-induced expression of Ifnb, Cxcl10, and Il6 mRNA in mouse embryonic fibroblasts (MEFs)^[1].
SN-011 (0.001-10 μM; pretreated for 6 h) inhibits 2′3′-cGAMP-induced Ifnb expression in MEFs, mouse bone marrow-derived macrophages (BMDMs) and human foreskin fibroblasts (HFFs) with IC₅₀s of 127.5, 107.1, and 502.8 nM, respectively^[1].
SN-011 (1 μM; pretreated for 3 h) inhibits 2′3′-cGAMP-induced STING oligomerization and phosphorylation in HFFs^[1].
SN-011 (1 μM) suppresses HSV-1 infection (4 h), HT-DNA (1 h), or 2′3′-cGAMP stimulation (30 min) induced STING ER-to-Golgi translocation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human foreskin fibroblasts
Concentration:

1 μM
Incubation Time:

Pretreated and then stimulated with 2′3′-cGAMP for 1 h
Result:

Suppressed 2′3′-cGAMP-induced STING oligomerization and phosphorylation.

In Vivo

SN-011 (5 mg/kg; i.p. 3 times weekly for a month) strongly inhibits hallmarks of inflammation and autoimmunity disease, and protects Trex1^/ mice from death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4-wk-old Trex1^−/− mice^[1]
Dosage:

5 mg/kg
Administration:

I.p. 3 times weekly for a month
Result:

Improved survival of mice.
Reduced severe multiorgan inflammation.
Reduced serum antinuclear antibody.

Chemical Information

CAS No. 2249435-90-1
Appearance Solid
Masse moléculaire 462.49
Formule C₂₅H₁₉FN₂O₄S
Color Off-white to gray
SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(C(NS(=O)(C4=CC=C(C=C4)F)=O)=C3)O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (15)

All WB2D/3D Cell Culture and DifferentiationCell Proliferation/Viability AssayCell Migration/Invasion Assay

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Journal Impact Factor

Exp Mol Med

DN203316, a novel PPARδ agonist, suppresses ferroptotic signaling and fibrogenesis in metabolic dysfunction-associated steatohepatitis. [Abstract]

2026 Jun;58(6):1900-1913. PMID: 42249087
Genes Dis

DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug. [Abstract]

2022 Oct 18;10(6):2557-2571. PMID: 37554214
Cell Death Differ

STING is the scaffold protein for stress granule pre-condensation at the ER. [Abstract]

2026 Apr 1. PMID: 41917183
Cell Death Differ

Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis. [Abstract]

2025 Nov 27. PMID: 41310183
J Immunother Cancer

Memory B cell subset shapes antitumor immunity and response to PD-1 blockade in mismatch repair-deficient colorectal cancers. [Abstract]

2026 Jan 8;14(1):e012121. PMID: 41506788
Proc Natl Acad Sci U S A

Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. [Abstract]

2025 Mar 25;122(12):e2420534122. PMID: 40112113
Br J Cancer

New mechanistic understanding of FXR agonist Vonafexor: inducing sublethal damage of HBV-positive liver cancer cells via promoting anti-tumor immunity. [Abstract]

2025 Sep;133(5):697-708. PMID: 40588513
Int Immunopharmacol

USP34 regulates PIN1-cGAS-STING axis-dependent ferroptosis in cervical cancer via SUMOylation. [Abstract]

2025 Jan 2:147:113968. PMID: 39752760

SN-011 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 2:147:113968. [Abstract]

SN-011 (24, 48, or 72 h) reversed the reduction in cell proliferation caused by PIN1 knockdown in HeLa cells treated with sh-PIN1 or SiHa cells treated with pcDNA-PIN1 and MSA-2 (24, 48, or 72 h).

SN-011 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 2:147:113968. [Abstract]

Transwell assay demonstrated decreased migratory potential in sh-PIN1-treated HeLa cells, which was partially reversed by SN-011 (24 h) treatment. Conversely, MSA-2 (24 h) reduced the migration of pcDNA-PIN1-treated SiHa cells.
PLoS Pathog

HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI. [Abstract]

2026 Jan 13;22(1):e1013868. PMID: 41529066
J Virol

The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1. [Abstract]

2023 Apr 27;97(4):e0018823. PMID: 37039642

SN-011 purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Apr 27;97(4):e0018823. [Abstract]

SN-011 (5 µM, 24 h) increased PRRSV protein expression in Marc-145 cells.

SN-011 purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Apr 27;97(4):e0018823. [Abstract]

SN-011 (5 µM, 24 h) increased PRRSV titers in Marc-145 cells.

SN-011 purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Apr 27;97(4):e0018823. [Abstract]

SN-011 (5 µM, 24 h) showed no effect on cell growth in Marc-145 cells.
J Gen Virol

SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING. [Abstract]

2026 Mar;107(3):002233. PMID: 41880208
bioRxiv

Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast Cancer. [Abstract]

2026 Jun 10:2026.06.05.730362. PMID: 42327017
bioRxiv

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING. [Abstract]

2026 May 29:2026.05.26.727520. PMID: 42244578
bioRxiv

2025 February 24.
bioRxiv

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses. [Abstract]

2024 Sep 5:2024.09.05.611469. PMID: 39282446

SN-011 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2024 Sep 5:2024.09.05.611469. [Abstract]

A549-ACE2 cells were pretreated with SN-011 for 16 h prior to viral infection. Cells were then infected with rSARS-CoV-2 (Nsp15WT and Nsp15H234A) at an MOI of [X] in the presence of SN-011 for 48 h. Supernatants were harvested for viral titration by plaque assay. Cell viability was determined by WST-1 assay after incubation with SN-011 for 72 h (black dotted line).

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (216.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1622 mL

10.8110 mL

21.6221 mL

5 mM

0.4324 mL

2.1622 mL

4.3244 mL

10 mM

0.2162 mL

1.0811 mL

2.1622 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hong Z, et, al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1622 mL	10.8110 mL	21.6221 mL	54.0552 mL
	5 mM	0.4324 mL	2.1622 mL	4.3244 mL	10.8110 mL
	10 mM	0.2162 mL	1.0811 mL	2.1622 mL	5.4055 mL
	15 mM	0.1441 mL	0.7207 mL	1.4415 mL	3.6037 mL
	20 mM	0.1081 mL	0.5406 mL	1.0811 mL	2.7028 mL
	25 mM	0.0865 mL	0.4324 mL	0.8649 mL	2.1622 mL
	30 mM	0.0721 mL	0.3604 mL	0.7207 mL	1.8018 mL
	40 mM	0.0541 mL	0.2703 mL	0.5406 mL	1.3514 mL
	50 mM	0.0432 mL	0.2162 mL	0.4324 mL	1.0811 mL
	60 mM	0.0360 mL	0.1802 mL	0.3604 mL	0.9009 mL
	80 mM	0.0270 mL	0.1351 mL	0.2703 mL	0.6757 mL
	100 mM	0.0216 mL	0.1081 mL	0.2162 mL	0.5406 mL

Keywords

SN-011

15 Cited Publications

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SN-011

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) SN-011

Activité biologique

Chemical Information

Publications (15)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

SN-011

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) SN-011

Activité biologique

Chemical Information

Publications (15)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

SN-011 Related Classifications

HY-145010 Related Classifications