Cat. No.: HY-N7271

Solanidine

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Based on 1 publication(s) in Google Scholar

Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice.

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Pureté: 99.90%
CAS No.: 80-78-4
Formule: C₂₇H₄₃NO
Masse moléculaire:397.64

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Solanidine Chemical Structure

CAS No.: 80-78-4

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

Solanidine (10 μM) increases the proliferation of MCF-7 human breast cancer cells in the estrogen-depleted condition^[1].
Solanidine (4-8 μM; 48 h) induces DNA damage in A549 cells and reduces the migration and invasion of A549 cells under hypoxic conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

A549 cells
Concentration:

4 μM, 8 μM
Incubation Time:

48 h
Result:

Decreased the expression of RAD51, elevated the expression of γH2AX, and increased the expression of tumor suppressor protein p53.
Inhibited the phosphorylation of ATM^ser1981, HIF-1α^ser696, and Chk2^Tyr68.

In Vivo

Solanidine (2.4 mmol/kg; p.o., dietary administration; 14 days) causes hepatomegaly in non-pregnant and pregnant mice, reduces body weight gains, litter weights, and average fetus weights in pregnant mice, and leads to abortions in some pregnant mice^[1].
Solanidine (4-8 μM; topical application; 7 days) reduces neovascularization in the alkali burn corneal model of rats^[2].
Solanidine (10-20 mg/kg; i.p.; every other day; 6 doses) regresses LLC tumor in Balb/C female mice, reduces the number of tumor nodules, and extends the survival of animals^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss Webster mice (female, 25-36 g, timed-pregnant at 1-2 days’ gestation) pregnant mice model^[1]
Dosage:

2.4 mmol/kg (in diet)
Administration:

Dietary administration, 14 days
Result:

Led to lower body weight gains, litter weights, and average fetus weights in pregnant mice.
Resulted in miscarriage in 5 of 24 pregnant mice.
Increased liver weight as a percentage of body weight (%LW/BW) in non-pregnant and pregnant mice.
Showed lower litter weight as a percentage of body weight (%LTW/BW).

Chemical Information

CAS No. 80-78-4
Appearance Solid
Masse moléculaire 397.64
Formule C₂₇H₄₃NO
Color White to off-white
SMILES

[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
- Alkaloids
- Piperidine Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Vet Microbiol

Identification and evaluation of Nordihydroguaiaretic acid (NDGA) as an active traditional Chinese medicine compound inhibiting the 3C-like protease of feline infectious peritonitis virus. [Abstract]

2025 Sep 15:310:110730. PMID: 40976146

Solvant et solubilité

In Vitro:

Ethanol : 3.33 mg/mL (8.37 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5148 mL

12.5742 mL

25.1484 mL

5 mM

0.5030 mL

2.5148 mL

5.0297 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Friedman M, et al. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 2003 Jan;41(1):61-71. [Content Brief]

[2]. Sherapura A, et al. Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma. Phytomedicine. 2023 Oct;119:154981. [Content Brief]

[3]. Zhang ZD, et al. Synthesis of Demissidine and Solanidine.Org Lett. 2016 Jun 17;18(12):3038-40. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	2.5148 mL	12.5742 mL	25.1484 mL	62.8709 mL
Ethanol	5 mM	0.5030 mL	2.5148 mL	5.0297 mL	12.5742 mL

Keywords

Solanidine

1 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Solanidine

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Solanidine Related Classifications

HY-N7271 Related Classifications