SPV106
Based on 1 Customer Validation
SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.59%
- CAS No.: 1036939-38-4
- Formule: C22H40O4
- Masse moléculaire:368.55
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
44.91 μM
Compound: 1b
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Induction of apoptosis in human U937 cells after 30 hrs using annexin V/propidium iodide double-staining by FACS analysis
Induction of apoptosis in human U937 cells after 30 hrs using annexin V/propidium iodide double-staining by FACS analysis
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[PMID: 21292492] |
In Vitro
SPV106 restores normal levels of H3K9Ac and H3K14Ac, reduces DNA CpG hypermethylation, and recovers D-CMSC proliferation and differentiation[1].
SPV106 (5 μmol/L) reduces cellular senescence and induces cKit expression in D-CMSC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human cardiac-specific mesenchymal cell (CMSC)
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Concentration:25 μmol/L
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Incubation Time:6-8 days
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Result:Achieved partial but significant rescue of HAT activity.
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Cell Line:Human cardiac-specific mesenchymal cell (CMSC)
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Concentration:25 μmol/L
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Incubation Time:7 days
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Result:Not associated to a rescue in gene transcription.
Chemical Information
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CAS No. 1036939-38-4
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Appearance Liquid
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Masse moléculaire 368.55
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Formule C22H40O4
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Color Colorless to light yellow
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SMILES
O=C(OCC)/C(C(OCC)=O)=C/CCCCCCCCCCCCCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (271.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.78 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7133 mL | 13.5667 mL | 27.1334 mL | 67.8334 mL |
| 5 mM | 0.5427 mL | 2.7133 mL | 5.4267 mL | 13.5667 mL | |
| 10 mM | 0.2713 mL | 1.3567 mL | 2.7133 mL | 6.7833 mL | |
| 15 mM | 0.1809 mL | 0.9044 mL | 1.8089 mL | 4.5222 mL | |
| 20 mM | 0.1357 mL | 0.6783 mL | 1.3567 mL | 3.3917 mL | |
| 25 mM | 0.1085 mL | 0.5427 mL | 1.0853 mL | 2.7133 mL | |
| 30 mM | 0.0904 mL | 0.4522 mL | 0.9044 mL | 2.2611 mL | |
| 40 mM | 0.0678 mL | 0.3392 mL | 0.6783 mL | 1.6958 mL | |
| 50 mM | 0.0543 mL | 0.2713 mL | 0.5427 mL | 1.3567 mL | |
| 60 mM | 0.0452 mL | 0.2261 mL | 0.4522 mL | 1.1306 mL | |
| 80 mM | 0.0339 mL | 0.1696 mL | 0.3392 mL | 0.8479 mL | |
| 100 mM | 0.0271 mL | 0.1357 mL | 0.2713 mL | 0.6783 mL |
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