STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance.
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- Formule: C25H27N5O
- Masse moléculaire:413.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
STAT5-IN-3 (Compound 14a) (100 nM-10 μM; 48 h) can inhibit the activity of myeloid leukemia cells (KU812, K562, KCL-22, MV-4-11, and MOLM-13) with EC50 values of 0.6 μM, 0.8 μM, 0.5 μM, 0.3 μM, and 0.3 μM, respectively. In contrast, STAT5-IN-3 exhibits low toxicity towards normal cells (HS27A and MSC), with EC50 values exceeding 10 μM for both cell types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 413.51
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Formule C25H27N5O
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SMILES
CC(CC1)(C)C2=C(C=CC=C2C3=CN=C(N)N=C3)N1CCOC4=CC=C5C(C=CN5)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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