TAPI-1 (Standard)
TAPI-1 (Standard) is the analytical standard of TAPI-1 (HY-16657). This product is intended for research and analytical applications. TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions.
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- CAS No.: 163847-77-6
- Formule: C26H37N5O5
- Masse moléculaire:499.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 163847-77-6
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Masse moléculaire 499.60
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Formule C26H37N5O5
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SMILES
O=C(N[C@@H](CC1=CC=C2C=CC=CC2=C1)C(N[C@@H](C)C(NCCN)=O)=O)[C@H](CC(C)C)CC(NO)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAPI-1 (Standard) Related Classifications
HY-16657R Related Classifications
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Keywords
- TAPI-1 (Standard)
- 163847-77-6
- Reference Standards
- MMP
- NF-κB
- Apoptosis
- TNF Receptor
- Matrix metalloproteinases
- Nuclear factor-κB
- Nuclear factor-kappaB
- Tumor Necrosis Factor Receptor
- TNFR
- esophageal squamous cell carcinoma cells
- NF-κB p65
- ADAM10
- TNF-α
- TE-1
- Het-1A
- MMPs
- myocardial infarction models
- ADAM17/TACE
- Eca109
- Inhibitor
- inhibitor
- inhibit