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Cat. No.: HY-120531

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UR-PI376

UR-PI376 is a potent and selective histamine H4 receptor (H4R) agonist with a pEC₅₀ value of 7.47. UR-PI376 shows negligible hH1R and hH2R activities and moderate inverse agonistic activity at the hH3R.

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CAS No.: 1192559-94-6
Formule: C₁₇H₂₂N₆S
Masse moléculaire:342.46

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

UR-PI376 Chemical Structure

CAS No.: 1192559-94-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IC₅₀ & Target

^[1]

Human H₄ Receptor

7.47 (pEC₅₀)

Voir tous les produits spécifiques à Isoform Histamine Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	EC₅₀	37 nM Compound: 1; UR-PI376	Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	[PMID: 27007611]
Sf9	EC₅₀	720 nM Compound: 1; UR-PI376	Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay	[PMID: 27007611]

Chemical Information

CAS No. 1192559-94-6
Masse moléculaire 342.46
Formule C₁₇H₂₂N₆S
SMILES

N#CN/C(NCCSC1=CC=CC=C1)=N\CCCCC2=CN=CN2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Patrick Igel, et al. Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. J Med Chem. 2009 Oct 22;52(20):6297-313. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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UR-PI376

Voir tous les produits spécifiques à Isoform Histamine Receptor

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

UR-PI376 Related Classifications

HY-120531 Related Classifications

Bioz

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