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Cat. No.: HY-113616

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VU0364572

VU0364572 is a selective allosteric agonist of the M1 muscarinic receptor with an EC₅₀ of 0.11 μM. VU0364572 has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 is orally active and is CNS penetrant.

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CAS No.: 1240514-87-7
Formule: C₂₁H₃₁N₃O₃
Masse moléculaire:373.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VU0364572 Chemical Structure

CAS No.: 1240514-87-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>30 μM Compound: 17, VU0364572	Agonist activity at rat muscarinic M2 receptor expressed in CHO cells Agonist activity at rat muscarinic M2 receptor expressed in CHO cells	[PMID: 21930376]
CHO	EC₅₀	>30 μM Compound: 17, VU0364572	Agonist activity at rat muscarinic M3 receptor expressed in CHO cells Agonist activity at rat muscarinic M3 receptor expressed in CHO cells	[PMID: 21930376]
CHO	EC₅₀	>30 μM Compound: 17, VU0364572	Agonist activity at rat muscarinic M4 receptor expressed in CHO cells Agonist activity at rat muscarinic M4 receptor expressed in CHO cells	[PMID: 21930376]
CHO	EC₅₀	>30 μM Compound: 17, VU0364572	Agonist activity at rat muscarinic M5 receptor expressed in CHO cells Agonist activity at rat muscarinic M5 receptor expressed in CHO cells	[PMID: 21930376]
CHO	EC₅₀	0.11 μM Compound: 17, VU0364572	Agonist activity at rat muscarinic M1 receptor expressed in CHO cells Agonist activity at rat muscarinic M1 receptor expressed in CHO cells	[PMID: 21930376]

In Vitro

VU0364572 (30 μM; 25 min) promotes KCNQ2, NR1 and MARCKS phosphorylation in striatal/NAc slices^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU0364572 (10 mg/kg/day; oral; 4 months) shows neuroprotective effects in 5XFAD transgenic Alzheimer’s mice. VU0364572 has a half life of 45 minutes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1240514-87-7
Masse moléculaire 373.49
Formule C₂₁H₃₁N₃O₃
SMILES

O=C(N1CCC(N2C[C@H](NC(C3=CC=CC=C3C)=O)CCC2)CC1)OCC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lebois EP, et al. Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model. ACS Chem Neurosci. 2017 Jun 21;8(6):1177-1187. [Content Brief]

[2]. Faruk MO, et al. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J Neurochem. 2022 Feb;160(3):325-341. [Content Brief]

[3]. Lebois EP, et al. Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6451-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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VU0364572

Voir tous les produits spécifiques à Isoform mAChR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VU0364572 Related Classifications

HY-113616 Related Classifications