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Cat. No.: HY-182618

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XAX-162

XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC₅₀ of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675).

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CAS No.: 883053-48-3
Formule: C₁₆H₁₅NO₂S₃
Masse moléculaire:349.49

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XAX-162 Chemical Structure

CAS No.: 883053-48-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
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Description

IC₅₀ & Target

S1PR2

0.55 μM (EC₅₀)

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In Vitro

XAX-162 (0.55 μM) activates S1PR2 in S1PR2 CRE-bla CHO cells with an EC₅₀ of 0.55 μM, reaching a maximum activity 130% of that induced by 1 μM S1P^[1].
XAX-162-mediated receptor activation is inhibited by JTE-013 (HY-100675) in a noncompetitive manner, with reduced response magnitude and right-shifted dose-response curves as JTE-013 concentration increases in S1PR2 CRE-bla CHO cells^[1].
XAX-162 is highly selective for S1PR2, showing no agonist activity in cell-based assays for S1PR1, S1PR3, S1PR4, or S1PR5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 883053-48-3
Masse moléculaire 349.49
Formule C₁₆H₁₅NO₂S₃
SMILES

CC(C=C1)=CC=C1SC2=CC=C(C3SCCS3)C=C2[N+]([O-])=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Satsu H, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013;21(17):5373-5382. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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XAX-162

Voir tous les produits spécifiques à Isoform LPL Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

XAX-162 Related Classifications

HY-182618 Related Classifications