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Cat. No.: HY-115440

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CRS3123 dihydrochloride

(Synonyms: REP-3123 dihydrochloride)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI).

For research use only. We do not sell to patients.

Purity: 99.11%
CAS No.: 1013915-99-5
Formula: C₁₉H₂₁Br₂Cl₂N₃O₂S
Molecular Weight:586.17

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

CRS3123 dihydrochloride Chemical Structure

CAS No.: 1013915-99-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1013915-99-5
Appearance Solid
Molecular Weight 586.17
Formula C₁₉H₂₁Br₂Cl₂N₃O₂S
Color White to off-white
SMILES

O=C1C2=C(C=CS2)NC(NCCCN[C@@H]3CCOC4=C(Br)C=C(Br)C=C34)=C1.[H]Cl.[H]Cl
Synonyms

REP-3123 dihydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Expert Opin Investig Drugs

New investigational agents for the treatment of Clostridioides difficile infections. [Abstract]

2025 Nov;34(11):869-885. PMID: 41117146

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (170.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7060 mL

8.5299 mL

17.0599 mL

5 mM

0.3412 mL

1.7060 mL

3.4120 mL

10 mM

0.1706 mL

0.8530 mL

1.7060 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Agent with Minimal Disruption of Normal Gut Microbiota. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01395-19. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7060 mL	8.5299 mL	17.0599 mL	42.6497 mL
	5 mM	0.3412 mL	1.7060 mL	3.4120 mL	8.5299 mL
	10 mM	0.1706 mL	0.8530 mL	1.7060 mL	4.2650 mL
	15 mM	0.1137 mL	0.5687 mL	1.1373 mL	2.8433 mL
	20 mM	0.0853 mL	0.4265 mL	0.8530 mL	2.1325 mL
	25 mM	0.0682 mL	0.3412 mL	0.6824 mL	1.7060 mL
	30 mM	0.0569 mL	0.2843 mL	0.5687 mL	1.4217 mL
	40 mM	0.0426 mL	0.2132 mL	0.4265 mL	1.0662 mL
	50 mM	0.0341 mL	0.1706 mL	0.3412 mL	0.8530 mL
	60 mM	0.0284 mL	0.1422 mL	0.2843 mL	0.7108 mL
	80 mM	0.0213 mL	0.1066 mL	0.2132 mL	0.5331 mL
	100 mM	0.0171 mL	0.0853 mL	0.1706 mL	0.4265 mL

CRS3123 dihydrochloride

1 Cited Publications

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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CRS3123 dihydrochloride

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Publications Citing Use of MedChemExpress (MCE) CRS3123 dihydrochloride

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CRS3123 dihydrochloride

Bioactive Compound Library Max

Bioactive Compound Library

Anti-Infection Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Antibacterial Compound Library

Antibiotics Library

Heterocyclic Compound Library

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CRS3123 dihydrochloride

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CRS3123 dihydrochloride Related Classifications

HY-115440 Related Classifications