2. Anti-infection
  3. Bacterial Antibiotic
  4. CRS3123 dihydrochloride

CRS3123 dihydrochloride  (Synonyms: REP-3123 dihydrochloride)

Cat. No.: HY-115440 Purity: 99.18%
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CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI).

For research use only. We do not sell to patients.

CRS3123 dihydrochloride Chemical Structure

CRS3123 dihydrochloride Chemical Structure

CAS No. : 1013915-99-5

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Based on 1 publication(s) in Google Scholar

Other Forms of CRS3123 dihydrochloride:

CRS3123 dihydrochloride Related Antibodies

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Description

CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI)[1].

Clinical Trial
Molecular Weight

586.17

Formula

C19H21Br2Cl2N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(C=CS2)NC(NCCCN[C@@H]3CCOC4=C(Br)C=C(Br)C=C34)=C1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (170.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7060 mL 8.5299 mL 17.0599 mL
5 mM 0.3412 mL 1.7060 mL 3.4120 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7060 mL 8.5299 mL 17.0599 mL 42.6497 mL
5 mM 0.3412 mL 1.7060 mL 3.4120 mL 8.5299 mL
10 mM 0.1706 mL 0.8530 mL 1.7060 mL 4.2650 mL
15 mM 0.1137 mL 0.5687 mL 1.1373 mL 2.8433 mL
20 mM 0.0853 mL 0.4265 mL 0.8530 mL 2.1325 mL
25 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7060 mL
30 mM 0.0569 mL 0.2843 mL 0.5687 mL 1.4217 mL
40 mM 0.0426 mL 0.2132 mL 0.4265 mL 1.0662 mL
50 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8530 mL
60 mM 0.0284 mL 0.1422 mL 0.2843 mL 0.7108 mL
80 mM 0.0213 mL 0.1066 mL 0.2132 mL 0.5331 mL
100 mM 0.0171 mL 0.0853 mL 0.1706 mL 0.4265 mL
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CRS3123 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRS31231013915-99-5REP-3123CRS 3123CRS-3123REP3123REP 3123BacterialAntibioticantibacterial agentmethionyl-tRNA synthetaseMetRSClostridioides difficileantibioticgut microbiotamicrobiomenarrow spectrumtoxin productionInhibitorinhibitorinhibit

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