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Cat. No.: HY-162051

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CYP1B1-IN-6

CYP1B1-IN-6 (compound 19) is a fluorescence molecular probes which inhibits CYP1B1 activity. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes.

For research use only. We do not sell to patients.

CAS No.: 2952712-68-2
Formula: C₇₁H₇₆FN₃O₂₂S₄
Molecular Weight:1470.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CYP1B1-IN-6 Chemical Structure

CAS No.: 2952712-68-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CYP1B1-IN-6 (compound 19) is a fluorescence molecular probes which inhibits CYP1B1 activity. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes^[1].

All Cytochrome P450 Isoforms :

Chemical Information

CAS No. 2952712-68-2
Molecular Weight 1470.63
Formula C₇₁H₇₆FN₃O₂₂S₄
SMILES

O=S(C1=C2C(C3=C([N+](CCCCCC(NCCOCCOCCOCCOC4=CC(C5=CC(C6=C(O5)C7=C(OC)C=CC(OC)=C7C(OC)=C6)=O)=CC(F)=C4)=O)=C(/C=C/C=C/C=C8N(CC)C9=C(C%10=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C%10C=C9)C/8(C)C)C3(C)C)C=C2)=CC(S(=O)(O)=O)=C1)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Bioluminescent/Fluorescent Imaging Xenograft
Bioluminescent and fluorescent imaging xenograft models use tumor cells engineered to express optical reporters so tumor engraftment, growth, dissemination, and treatment response can be monitored longitudinally in living animals and validated ex vivo. Bioluminescence imaging usually measures luciferase activity after substrate administration and is commonly used as a surrogate for viable reporter-expressing tumor burden, while fluorescence imaging measures reporter or probe emission and can support tumor localization, ex vivo confirmation, or complementary multimodal analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen D, et al. Design and Synthesis of Novel Near-Infrared Fluorescence Probes Based on an Open Conformation of a Cytochrome P450 1B1 Complex for Molecular Imaging of Colorectal Tumors. J Med Chem. 2023 Dec 14;66(23):16032-16050. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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