Dalfopristin mesylate  (Synonyms: RP54476 mesylate)

Dalfopristin (RP54476) mesylate is a semisynthetic sulfone antibiotic. Dalfopristin mesylate alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci^[1].

Dalfopristin (12 mg/kg/day, i.v., 7 days) mesylate shows no effects on hepatic cytochrome P-450 metabolite complexes in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

786.95

C₃₅H₅₄N₄O₁₂S₂

O=S(CC[NH+](CC)CC)([C@H]1[C@@](C(O[C@H]([C@@H](/C=C/C(NC/C=C\C(C)=C\2)=O)C)C(C)C)=O)([H])N(C(C3=COC(CC(C[C@@H]2O)=O)=N3)=O)CC1)=O.CS([O-])(=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. A Le Liboux, et al. Simultaneous high-performance liquid chromatographic determination of quinupristin, dalfopristin and their main metabolites in human plasma. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):161-8.  [Content Brief]

  [2]. Martinet MR, et al. Lack of effect of streptogramins on hepatic drug metabolism enzymes in the rat. Drug Metab Dispos. 1992 Jul-Aug;20(4):490-5.  [Content Brief]