Art. -Nr.: HY-W728531

Ac4ManNAz

17 Cited Publications

Kundenbewertung

Based on 17 publication(s) in Google Scholar

Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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Reinheit: 99.94%
CAS. Nr.: 1213701-11-1
Formel: C₁₆H₂₂N₄O₁₀
Molecular Weight:430.37

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ac4ManNAz Chemical Structure

CAS. Nr.: 1213701-11-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (17)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

In Vitro

Ac4ManNAz (0-50 μM, 72 h) upregulates MAPK activity-related genes (TLR4, THBS1, FPR1) and downregulates cell cycle, proliferation and cell adhesion-related genes like CYBB, GABRA1, SLC6A2, AKAP7)^[2].
Ac4ManNAz (0-50 μM, 30 h) inhibits voltage-gated potassium channel, inhibits the cell migration and invasion in A549, and impairs the mitochondrial functions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[2]

Cell Line:

A549
Concentration:

50 μM
Incubation Time:

30 h
Result:

Inhibited cell migration.

Chemical Information

CAS. Nr. 1213701-11-1
Appearance Solid
Molecular Weight 430.37
Formel C₁₆H₂₂N₄O₁₀
Color White to off-white
SMILES

CC(O[C@@H]1[C@@H]([C@H](O[C@@H]([C@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CN=[N+]=[N-])=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (17)

All OthersRT-PCRCell Imaging/Staining

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Journal Impact Factor

Adv Mater

A Dendritic Cell-Nanogel Conjugate for Tumor-Draining Lymph Node-Specific PD-L1 Blockade. [Abstract]

2025 Jul 7:e2504733. PMID: 40619999

Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Jul 7:e2504733. [Abstract]

Scheme illustration of the preparation of tumor-lysate pulsed DC vaccines (DCVs). BMDCs were incubated with 50 μM Ac4ManNAz and tumor lysates for 48 h.
Adv Mater

Dendritic Cell-Based Biohybrid Immunomodulator Alleviates Intestinal Inflammatory Disease. [Abstract]

2025 Jun 22:e2420113. PMID: 40545797
J Extracell Vesicles

PREDICTOR: A Non-Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs. [Abstract]

2026 Apr;15(4):e70282. PMID: 41979055
Adv Funct Mater

2025 Nov 12.
ACS Nano

Decoration of Biomimetic DNA Receptors on Macrophages for Precise and Logical Manipulation of Pathogen Predation. [Abstract]

2025 May 27;19(20):18986-18995. PMID: 40358040
Acta Pharm Sin B

2025 Dec 23.
Adv Sci (Weinh)

Light-Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction. [Abstract]

2026 May 6:e75519. PMID: 42089450
Adv Sci (Weinh)

A Spatially Distributed Microneedle System for Bioorthogonal T Cell-Guided Cancer Therapy. [Abstract]

2025 Feb 8:e2416841. PMID: 39921874
Acta Biomater

Strain-promoted click chemistry boosts microbubbles for targeted ultrasound imaging and cancer chemotherapy. [Abstract]

2026 Jul:218:510-524. PMID: 42248283
Acta Pharmacol Sin

Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer. [Abstract]

2025 Aug 8. PMID: 40781495
Acta Biomater

Engineered bioorthogonal cell delivery system for in situ antimicrobial peptide recruitment during systemic bacterial infection. [Abstract]

2025 Apr 10:S1742-7061(25)00265-X. PMID: 40220946
Int J Nanomedicine

Interleukin-2 Surface Displayed M1 Macrophage-Derived Extracellular Vesicles for Modulating the Tumor Microenvironment. [Abstract]

2025 Nov 26:20:14185-14200. PMID: 41332502

Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200. [Abstract]

Ac4ManNAz (50 μM; 72 h). qRT-PCR analysis comparing the relative expression level of IL-1β between M1 macrophages and Ac4ManNAz-treated M1 macrophages (Ac4/M1).

Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200. [Abstract]

Ac4ManNAz (50 μM; 72 h). Fluorescence microscopy imaging of macrophages labeled with DBCO-Cy5 after Ac4ManNAz treatment. Hoechst staining shows nuclei (blue), while DBCO-Cy5 indicates successful surface labeling (red). The merged image highlights specific azide-dependent bioorthogonal chemistry, with scale bars representing 100 µm.

Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200. [Abstract]

Ac4ManNAz (50 μM; 72 h). Morphological comparison of M0, M1, and Ac4ManNAz-treated M1 macrophages.

Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200. [Abstract]

Ac4ManNAz (50 μM; 72 h). qRT-PCR results showing that with Ac4ManNAz-treated M1EV (Ac4M1EV) significantly upregulated M1 macrophage markers IL-1β and CXCL10, while downregulating the M2 macrophage marker CD206 compared with M0 macrophages.
Anal Chem

A Spatial Coding Strategy for In Situ Visualization of RNA-Specific Glycoforms. [Abstract]

2026 Mar 24;98(11):8143-8154. PMID: 41810699
Talanta

Dual-gold nanoprobe system enables highly sensitive SERS detection of glycosylated CEs1 in HepG-2 cell culture supernatant. [Abstract]

2026 Jul 1:304:129561. PMID: 41722413
Oncogenesis

GlycoRNAs are abundant in glioma and involved in glioma cell proliferation. [Abstract]

2025 Oct 1;14(1):29. PMID: 41028727
Biophys J

Inhibition of endocytosis by glycans arises from steric rather than electrostatic repulsion. [Abstract]

2026 Mar 13:S0006-3495(26)00198-0. PMID: 41832605
bioRxiv

2025 Aug 08.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (232.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3236 mL

11.6179 mL

23.2358 mL

5 mM

0.4647 mL

2.3236 mL

4.6472 mL

10 mM

0.2324 mL

1.1618 mL

2.3236 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Spiciarich DR, et, al. Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics. Angew Chem Int Ed Engl. 2017 Jul 24;56(31):8992-8997. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3236 mL	11.6179 mL	23.2358 mL	58.0896 mL
	5 mM	0.4647 mL	2.3236 mL	4.6472 mL	11.6179 mL
	10 mM	0.2324 mL	1.1618 mL	2.3236 mL	5.8090 mL
	15 mM	0.1549 mL	0.7745 mL	1.5491 mL	3.8726 mL
	20 mM	0.1162 mL	0.5809 mL	1.1618 mL	2.9045 mL
	25 mM	0.0929 mL	0.4647 mL	0.9294 mL	2.3236 mL
	30 mM	0.0775 mL	0.3873 mL	0.7745 mL	1.9363 mL
	40 mM	0.0581 mL	0.2904 mL	0.5809 mL	1.4522 mL
	50 mM	0.0465 mL	0.2324 mL	0.4647 mL	1.1618 mL
	60 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.9682 mL
	80 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7261 mL
	100 mM	0.0232 mL	0.1162 mL	0.2324 mL	0.5809 mL

Keywords

Ac4ManNAz

17 Cited Publications

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Ac4ManNAz

Publications Citing Use of MedChemExpress (MCE) Ac4ManNAz

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (17)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ac4ManNAz Related Classifications

HY-W728531 Related Classifications