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Art. -Nr.: HY-P12357

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CD27 peptide

CD27 peptide is a 13-amino acid peptide derived from CD27. CD27 peptide is a targeting ligand for CD70 and can be used to construct CD70-targeted peptide amphiphile micelles. CD27 peptide can be used for research on melanoma and clear cell renal cell carcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3037125-72-4
Formel: C₅₄H₉₂N₁₈O₁₇S₃
Molecular Weight:1361.61

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

CD27 peptide Chemical Structure

CAS. Nr.: 3037125-72-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CD27 peptide (99:1 peptide:siRNA ratio; 1 h) incorporation into HIF2α-CD27 PAMs successfully retains HIF2α siRNA and protects it from RNase degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Animal Model:

C57BL/6 (Female human CD27 transgenic (hCD27), aged 6-12 weeks)^[2]
Dosage:

100 µg
Administration:

i.p.; on days 3 and 6 after tumor implantation
Result:

Increased Ova(I)-specific CD8+ T cells from ~20% to ~50% of the CD8+ TIL population.
Extended median survival by 18 days compared to control animals.\nProlonged survival in the setting of vaccines comprised of linked class I and II epitopes (Ova(I-IIA)).
Had no effect on survival with Ova(I) or Ova(I) + Ova(IIA) vaccines.\nProlonged survival in hCD27 mice bearing intracranial B16.OVA tumors.

Animal Model:

C57BL/6 (Female human CD27 transgenic (hCD27), aged 6-12 weeks)^[2]
Dosage:

100 µg
Administration:

i.p.; on days 3 and 6 after tumor implantation
Result:

Prolonged survival in mice bearing 3-day established intracranial B16.F10 tumors when combined with Trp2(I)-P30.
Had no effect on survival relative to control groups when combined with Trp2(I).

Chemical Information

CAS. Nr. 3037125-72-4
Molecular Weight 1361.61
Formel C₅₄H₉₂N₁₈O₁₇S₃
Sequence

Cys-Arg-Lys-Ala-Ala-Gln-Cys-Asp-Pro-Cys-Ile-Pro-Gly
Sequence Shortening

CRKAAQCDPCIPG
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Trac N, et al. CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells. Molecules (Basel, Switzerland). 2022 Dec 02;27(23):8457.

[2]. Riccione KA, et al. CD27 stimulation unveils the efficacy of linked class I/II peptide vaccines in poorly immunogenic tumors by orchestrating a coordinated CD4/CD8 T cell response. Oncoimmunology. 2018 Sep 5;7(12):e1502904.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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