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Art. -Nr.: HY-153023

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PROTAC STAT3 degrader-2

PROTAC STAT3 degrader-2 is a PROTAC degrader that targets STAT3, with a DC₅₀ value of 3.54 μM. PROTAC STAT3 degrader-2 inhibits the growth of leukemia and lymphoma cells with high levels of phosphorylated STAT3. PROTAC STAT3 degrader-2 is used in the research of acute myeloid leukemia and anaplastic large cell lymphoma.
(Pink: STAT3 ligand (HY-187011); Blue: Cereblon ligand (HY-W039116); Black: linker (HY-69220)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2429877-78-9
Formel: C₅₉H₆₀F₂N₉O₁₃P
Molecular Weight:1172.13

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Data Sheet (279 KB)

PROTAC STAT3 degrader-2 Chemical Structure

CAS. Nr.: 2429877-78-9

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC STAT3 degrader-2 is a PROTAC degrader that targets STAT3, with a DC₅₀ value of 3.54 μM. PROTAC STAT3 degrader-2 inhibits the growth of leukemia and lymphoma cells with high levels of phosphorylated STAT3. PROTAC STAT3 degrader-2 is used in the research of acute myeloid leukemia and anaplastic large cell lymphoma^[1]. (Pink: STAT3 ligand (HY-187011); Blue: Cereblon ligand (HY-W039116); Black: linker (HY-69220)).

IC₅₀ & Target

^[1]

STAT3

3.54 μM (ID₅₀)

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle STAT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SU-DHL-1	IC₅₀	>10 μM Compound: 27	Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay	[PMID: 31747516]

In Vitro

PROTAC STAT3 degrader-2 (Compound 27) (4 h) degrades total STAT3 protein in Molm-16 human acute myeloid leukemia cells, with a STAT3 degradation DC₅₀ value of 3.54 μM^[1].
PROTAC STAT3 degrader-2 (4 days) exhibits a cell growth inhibitory IC₅₀ value of 0.582 μM in Molm-16 human acute myeloid leukemia cells^[1].
PROTAC STAT3 degrader-2 (Up to 5 μM) is ineffective at degrading STAT3 protein in SU-DHL-1 human anaplastic large cell lymphoma cells after 16 hours of treatment^[1].
PROTAC STAT3 degrader-2 (Up to 10 μM) has no measurable growth inhibitory activity against SU-DHL-1 human anaplastic large cell lymphoma cells after 4 days of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Western Blot Analysis^[1]

View Protocol

Cell Line:

SU-DHL-1 anaplastic large cell lymphoma cell line
Concentration:

Up to 5 μM
Incubation Time:

16 h
Result:

Does not reduce total STAT3 or pSTAT3 (Y705) protein levels in SU-DHL-1 cells at concentrations up to 5 μM.

Cell Viability Assay^[1]

View Protocol

Cell Line:

SU-DHL-1 anaplastic large cell lymphoma cell line
Concentration:

Up to 10 μM
Incubation Time:

4 days
Result:

Does not inhibit SU-DHL-1 cell growth at concentrations up to 10 μM.

Chemical Information

CAS. Nr. 2429877-78-9
Appearance Solid
Molecular Weight 1172.13
Formel C₅₉H₆₀F₂N₉O₁₃P
Color White to off-white
SMILES

O=C1C2=C(C#CCCCCCC(N3C[C@@H](C(N4[C@@](CC[C@H]4C(N[C@@H](CCC(N)=O)C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)=O)([H])CC3)=O)NC(C7=CC8=CC(C(F)(F)P(O)(O)=O)=CC=C8N7)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhou H, et al. Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. Journal of medicinal chemistry. 2019 Dec 26;62(24):11280-11300. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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