Tissue Factor/CD142
Tissue factor/CD142 is a 47 kDa type I transmembrane glycoprotein encoded by the F3 gene that initiates blood coagulation through the extrinsic pathway. It is normally absent from cells in direct contact with blood, constitutively expressed in subendothelial adventitial cells and brain, and induced on monocytes and endothelium by inflammatory stimuli. Upon vascular injury it binds factor VII/VIIa, and the resulting complex proteolytically activates factor X, while factor VIIa signaling through PAR2 links coagulation to inflammation and angiogenesis. CD142 expression marks procoagulant monocytes in thromboinflammation, and natural inhibitors of the factor VIIa-tissue factor complex such as TFPI regulate this initiating step.
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Tissue Factor/CD142 Recombinant Proteins (6)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
