(R)-Colchicine
(R)-Colchicine is the R-isomer of Colchicine (HY-16569). Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.
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- CAS. Nr.: 75520-89-7
- Formel: C22H25NO6
- Molecular Weight:399.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Chemical Information
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CAS. Nr. 75520-89-7
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Molecular Weight 399.44
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Formel C22H25NO6
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SMILES
COC1=C2C(C([C@@H](CCC2=CC(OC)=C1OC)NC(C)=O)=C3)=CC=C(OC)C3=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218(1):189-200. [Content Brief]
[2]. Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51(3):377-401. [Content Brief]
[3]. Yuanjun Tang, et al. Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol. 2021 Dec 16:12:804030. [Content Brief]
[4]. Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587. [Content Brief]
[5]. Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143. [Content Brief]
[6]. Torin Huzil J, et al. Computational design and biological testing of highly cytotoxic colchicine ring A modifications. Chem Biol Drug Des. 2010 Jun;75(6):541-50. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(R)-Colchicine Related Classifications
Art. -Nr.: HY-W741136
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- (R)-Colchicine
- 75520-89-7
- Drug Isomer
- Microtubule/Tubulin
- NOD-like Receptor (NLR)
- Autophagy
- Apoptosis
- Orally
- alkaloid
- tubulin
- microtubule
- α3 glycine receptors
- GlyRs
- non-steroidal anti-inflammatory drug
- NSAID
- intestinal injury
- immunosuppressive
- anti-fibrosis
- gouty arthritis
- Alzheimer’s disease
- AD
- Inhibitor
- inhibitor
- inhibit