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Art. -Nr.: HY-141895

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Vps34-IN-3

Vps34-IN-3 is a potent, selective, and orally bioavailable VPS34 kinase inhibitor.

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CAS. Nr.: 2770104-92-0
Formel: C₁₄H₂₀N₄O₂
Molecular Weight:276.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Vps34-IN-3 Chemical Structure

CAS. Nr.: 2770104-92-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Vps34-IN-3 is a potent, selective, and orally bioavailable VPS34 kinase inhibitor.

Alle PI3K Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	200 nM Compound: 5	Inhibition of autophagy in GFP-FYVE tagged human U2OS cells assessed as decrease in PI3P-mediated GFP-puncta formation by Hoechst 33258 staining based fluorescence microscopic analysis Inhibition of autophagy in GFP-FYVE tagged human U2OS cells assessed as decrease in PI3P-mediated GFP-puncta formation by Hoechst 33258 staining based fluorescence microscopic analysis	[PMID: 34779204]

Chemical Information

CAS. Nr. 2770104-92-0
Molecular Weight 276.33
Formel C₁₄H₂₀N₄O₂
SMILES

C[C@H]1N(C2=NN([C@H](CCC3)[C@H]3NC4=O)C4=C2)CCOC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hu DX, et al. Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 2021 Nov 15. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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Vps34-IN-3

Alle PI3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Vps34-IN-3 Related Classifications

HY-141895 Related Classifications