USP11 - ubiquitin specific peptidase 11 Gene

Also Known as UHX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8237

About USP11

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,233,009-47,248,328 (from NCBI)

This gene has 12 transcripts (splice variants), 192 orthologues and 71 paralogues. Broad expression in brain (RPKM 81.8), ovary (RPKM 32.3) and 22 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

USP11 Products (1)

mRNA	Protein	Name
NM_001371072.1	NP_001358001.1	ubiquitin carboxyl-terminal hydrolase 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	15314155	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	28992046	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15314155	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	15314155	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	28992046	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15314155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP11 Protein Structure

DUSP

Ubiquitin_3

UCH

0
200
400
600
800
963 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 11	deubiquitinating enzyme 11

USP11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	USP11	P51784	PALB2	Homo sapiens	Q86YC2	Anti Bait CoIP	26649820
Intra	USP11	P51784	BMI1	Homo sapiens	P35226	Anti Tag CoIP	20601937
Intra	USP11	P51784	DECR2	Homo sapiens	Q9NUI1	Y2H Prey Pooling	32296183
Intra	USP11	P51784	DECR2	Homo sapiens	Q9NUI1	Validated Y2H	32296183
Intra	USP11	P51784	DECR2	Homo sapiens	Q9NUI1	Y2H Array	32296183
Intra	USP11	P51784	CBX8	Homo sapiens	Q9HC52	Pull Down	20601937
Intra	USP11	P51784	CBX8	Homo sapiens	Q9HC52	Anti Tag CoIP	20601937
Cross	USP11	P51784	E7	Human papillomavirus	P03129	Anti Tag CoIP	18408009
Cross	USP11	P51784	tat	Human immunodeficiency virus	P04608	Pull Down	22190034
Cross	USP11	P51784	NP	Influenza A virus	Q9DLK6	Anti Tag CoIP	20924359

Cross: Cross-species interaction Intra: Intraspecies interaction

USP11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82101	USP11 Antibody (YA1846)	WB, IP, FC	Human, Mouse, Rat
HY-P82101A	USP11 Antibody (YA1846)(PBS only)	WB, IP, FC	Human, Mouse, Rat
HY-P84377	USP11 Antibody (YA4074)	WB, FC	Human
HY-P84377A	USP11 Antibody (YA4074)(PBS only)	WB, FC	Human

Related Diseases

Diseases	Alias
Bronchiectasis	Polynesian Bronchiectasis Kartagener Syndrome Bronchiectasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180171	USP11-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP11	RGD	RGD:1303052
Felis catus	USP11	VGNC	VGNC:66865
Bos taurus	USP11	VGNC	VGNC:36711
Canis familiaris	USP11	VGNC	VGNC:54609
Mus musculus	USP11	MGD	MGI:2384312
Macaca mulatta	USP11	VGNC	VGNC:78734
Others	USP11	NCBI