(-)-Halofantrine
(-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) is an inhibitor of the malignant malaria parasite (P. falciparum) and targets multidrug-resistant P. falciparum. The pharmacokinetic parameters of (-)-Halofantrine in rats vary depending on the route of administration, distinguishing it from other isomers.
For research use only. We do not sell to patients.
- CAS No.: 66051-76-1
- Formula: C26H30Cl2F3NO
- Molecular Weight:500.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
P. falciparum[1]
| Route | Dose (mg/kg) | Compound | AUC0-∞ (mg·h/L) | Cl (mL/h/kg) | Vdss (L/kg) | Vdβ (L/kg) | t1/2 (h) | Cmax (ng/mL) | tmax (h) |
| i.v. | 2; n=5 | (-)-Halofantrine | 5.02 | 199 | 3.22 | 4.64 | 16.8 | / | / |
| (+)-Halofantrine | 9.06 | 113 | 2.38 | 3.13 | 20.8 | / | / | ||
| (±)-Halofantrine | 14.1 | 143 | 3.53 | 3.60 | 18.0 | / | / | ||
| p.o. | 14; n=5 | (-)-Halofantrine | 5.49 | / | / | / | 16.6 | 556 | 2.20 |
| (+)-Halofantrine | 16.3 | / | / | / | 16.5 | 917 | 4.20 | ||
| (±)-Halofantrine | 22.5 | / | / | / | 16.4 | 1420 | 3.60 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 66051-76-1
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Molecular Weight 500.42
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Formula C26H30Cl2F3NO
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SMILES
OC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31.[Rotation (-)]
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Synonyms
(-)-SKF-102886 free base; (-)-WR-171669
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Halofantrine Related Classifications
HY-A0148B Related Classifications
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