MitoSOX Red
Based on 312 publication(s) in Google Scholar
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.
For research use only. We do not sell to patients.
- Purity: 95.86%
- CAS No.: 1003197-00-9
- Formula: C43H43IN3P
- Molecular Weight:759.70
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Storage:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications Citing Use of MedChemExpress (MCE) MitoSOX Red
More- Signal Transduct Target Ther. 2026 Mar 26;11(1):113. [Abstract]
- Science. 2026 Apr 23;392(6796):eadw2156. [Abstract]
- Imeta. 2026 Jun 14.
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- Mol Cancer. 2024 Jul 4;23(1):136. [Abstract]
- Nat Nanotechnol. 2025 Jul;20(7):935-946. [Abstract]
- Immunity. 2025 Aug 25:S1074-7613(25)00333-4. [Abstract]
- Adv Mater. 2025 Jul;37(27):e2500156. [Abstract]
- Cell Mol Immunol. 2025 Jul;22(7):776-790. [Abstract]
- Bioact Mater. 2026 Jan 7:59:642-661. [Abstract]
- Nat Cell Biol. 2026 Apr;28(4):812-827. [Abstract]
- Adv Funct Mater. 2025 Feb 28.
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- Autophagy. 2026 Jun 29:1-20. [Abstract]
- Autophagy. 2026 Jun 25:1-16. [Abstract]
- Autophagy. 2026 May 25. [Abstract]
- Nat Commun. 2026 Jun 9;17(1):5072. [Abstract]
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- J Adv Res. 2026 Mar 20:S2090-1232(26)00264-X. [Abstract]
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- J Adv Res. 2025 Oct 10:S2090-1232(25)00764-7. [Abstract]
- Redox Biol. 2026 Jun 22:95:104272. [Abstract]
- Redox Biol. 2026 Jun 11:95:104255. [Abstract]
- Redox Biol. 2025 Oct:86:103847. [Abstract]
- Redox Biol. 2025 Sep 10:87:103867. [Abstract]
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- Phytomedicine. 2026 Jul 25:157:158316. [Abstract]
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- Mater Today Adv. 2026 Feb 10.
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- Free Radic Biol Med. 2025 Dec 31:245:223-236. [Abstract]
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- Free Radic Biol Med. 2025 Jun 14:237:585-599. [Abstract]
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- Free Radic Biol Med. 2024 Nov 1:224:831-845. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:15-27. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:111-124. [Abstract]
- J Genet Genomics. 2026 Jan 9:S1673-8527(26)00002-0. [Abstract]
- J Anim Sci Biotechnol. 2025 May 24;16(1):74. [Abstract]
- ACS Appl Mater Interfaces. 2026 May 27. [Abstract]
- ACS Appl Mater Interfaces. 2026 Mar 11;18(9):13420-13436. [Abstract]
- ACS Appl Mater Interfaces. 2025 Dec 24;17(51):69180-69195. [Abstract]
- ACS Appl Mater Interfaces. 2025 Jun 4;17(22):31828-31842. [Abstract]
- Br J Cancer. 2025 Apr 11. [Abstract]
- Stem Cell Res Ther. 2024 Dec 18;15(1):471. [Abstract]
- Aging Cell. 2026 Jun;25(6):e70575. [Abstract]
- Cell Rep. 2026 Jun 9;45(6):117515. [Abstract]
- Cell Rep. 2026 Mar 27;45(4):117183. [Abstract]
- Aging Cell. 2025 Feb;24(2):e14391. [Abstract]
- Cell Rep. 2024 Jan 3;43(1):113658. [Abstract]
- Brain Behav Immun. 2026 May 19:137:106821. [Abstract]
- J Pineal Res. 2026 Mar;78(2):e70133. [Abstract]
- Brain Behav Immun. 2026 Feb:132:106208. [Abstract]
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- Environ Pollut. 2024 Mar 15:345:123467. [Abstract]
- Redox Rep. 2026 Dec;31(1):2622255. [Abstract]
- Redox Rep. 2025 Dec;30(1):2536400. [Abstract]
- J Ethnopharmacol. 2026 Jul 15:366:121624. [Abstract]
- J Ethnopharmacol. 2026 Mar 25:359:121067. [Abstract]
- J Ethnopharmacol. 2026 Feb 28:357:120941. [Abstract]
- J Ethnopharmacol. 2026 Apr 24:361:121230. [Abstract]
- Antioxid Redox Signal. 2025 Feb;42(4-6):184-198. [Abstract]
- J Agric Food Chem. 2026 Jan 28;74(3):3040-3052. [Abstract]
- Biomater Adv. 2026 Mar:180:214576. [Abstract]
- NanoImpact. 2025 Jul:39:100572. [Abstract]
- J Agric Food Chem. 2025 Apr 10. [Abstract]
- J Agric Food Chem. 2025 Mar 26;73(12):7432-7444. [Abstract]
- CNS Neurosci Ther. 2026 Apr;32(4):e70885. [Abstract]
- Ecotoxicol Environ Saf. 2025 Sep 15:303:118920. [Abstract]
- Ecotoxicol Environ Saf. 2025 Apr 15:295:118139. [Abstract]
- Ecotoxicol Environ Saf. 2025 Jan 1:289:117693. [Abstract]
- Ecotoxicol Environ Saf. 2024 Jan 1:269:115906. [Abstract]
- Biochem Pharmacol. 2026 Jun 4;251(Pt 2):118122. [Abstract]
- Cell Mol Life Sci. 2025 Nov 14;82(1):406. [Abstract]
- Biochem Pharmacol. 2025 Jun:236:116867. [Abstract]
- Biochem Pharmacol. 2025 Jun:236:116868. [Abstract]
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- Life Sci. 2025 Mar 15:365:123452. [Abstract]
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- Plant J. 2025 Jul;123(1):e70322. [Abstract]
- Inflamm Res. 2025 Jan 7;74(1):6. [Abstract]
- Food Biosci. 2024 Oct.
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- Drug Des Devel Ther. 2025 Dec 1:19:10645-10660. [Abstract]
- Cancer Immunol Immunother. 2025 Aug 25;74(9):293. [Abstract]
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- Eur J Pharmacol. 2025 Oct 15:1005:178118. [Abstract]
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- Int Immunopharmacol. 2026 Jan 1;168(Pt 2):115924. [Abstract]
- Int J Mol Sci. 2025 Dec 12;26(24):11970. [Abstract]
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- Int J Mol Sci. 2025 Sep 20;26(18):9185. [Abstract]
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- Int Immunopharmacol. 2025 Apr 24:153:114463. [Abstract]
- Int Immunopharmacol. 2025 Feb 20:148:114048. [Abstract]
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- Int J Mol Sci. 2025 Feb 5;26(3):1350. [Abstract]
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- Int J Mol Sci. 2023 Nov 25;24(23):16756. [Abstract]
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
Biological Activity
Excitation/emission wavelength: 510/580 nm.
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Preparation of MitoSOX Red working solution
1.1 Preparation of the stock solution
Dissolve MitoSOX Red in DMSO to obtain 5 mM of stock solution.
Note: This stock solution is stable for one day.
1.2 Preparation of MitoSOX Red working solution
Dilute the stock solution in serum-free cell culture medium or PBS to obtain 1-10 μM of working solution.
Note: Please adjust the concentration of MitoSOX Red working solution according to the actual situation.
2. Cell staining (Suspension cells)
2.1 Centrifuge at 1000 g at 4°C for 3-5 minutes and then discard the supernatant. Wash twice with PBS, 5 minutes each time. The cell density is 1×106/mL.
2.2 Add 1 mL of working solution, and then incubate at room temperature for 5-30 minutes.
2.3 Centrifuge at 400 g at 4°C for 3-4 minutes and then discard the supernatant.
2.4 Wash twice with PBS, 5 minutes each time.
2.5 Resuspend cells with serum-free cell culture medium or PBS. Observation by fluorescence microscopy or flow cytometry.
3. Cell staining (Adherent cells)
3.1 Culture adherent cells on sterile coverslips.
3.2 Remove the coverslip from the medium and aspirate excess medium.
3.3 Add 100 μL of working solution, gently shake it to completely cover the cells, and then incubate at room temperature for 5-30 minutes.
3.4 Wash twice with medium, 5 minutes each time. Observation by fluorescence microscopy or flow cytometry.
Precautions
1. Please adjust the concentration of MitoSOX Red working solution according to the actual situation.
2. This product is for R&D use only, not for drug, household, or other uses.
3. For your safety and health, please wear a lab coat and disposable gloves to operate.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
580
510
Chemical Information
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CAS No. 1003197-00-9
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Appearance Solid
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Molecular Weight 759.70
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Formula C43H43IN3P
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Color Yellow to brown
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SMILES
NC1=CC(C(C2=CC=CC=C2)N(CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(N)=CC=C76)=C7C=C1.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (312)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer. [Abstract]2026 Mar 26;11(1):113. PMID: 41888107 -
Science
Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq. [Abstract]2026 Apr 23;392(6796):eadw2156. PMID: 42024736 -
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Mol Cancer
HPGD induces ferroptosis and autophagy to suppress esophageal squamous cell carcinoma through the LXA4-ERK1/2-U2AF2-TFRC axis. [Abstract]2025 Oct 2;24(1):241. PMID: 41039452 -
Mol Cancer
Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma. [Abstract]2024 Jul 4;23(1):136. PMID: 38965534 -
Nat Nanotechnol
An orally administered gene editing nanoparticle boosts chemo-immunotherapy in colorectal cancer. [Abstract]2025 Jul;20(7):935-946. PMID: 40269250 -
Immunity
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease. [Abstract]2025 Aug 25:S1074-7613(25)00333-4. PMID: 40902587 -
Adv Mater
Signal Converter-Based Therapy Platform Promoting Aging Bone Healing by Improving Permeability of the Mitochondrial Membrane. [Abstract]2025 Jul;37(27):e2500156. PMID: 40289881 -
Cell Mol Immunol
Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagy. [Abstract]2025 Jul;22(7):776-790. PMID: 40389600 -
Bioact Mater
On-demand mild photothermal cascade platform reprogramming mitochondrial immunity for tendon rejuvenation. [Abstract]2026 Jan 7:59:642-661. PMID: 41560899 -
Nat Cell Biol
TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy. [Abstract]2026 Apr;28(4):812-827. PMID: 41803502 -
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Autophagy
Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration. [Abstract]2026 Jun 29:1-20. PMID: 42329074 -
Autophagy
2026 Jun 25:1-16. PMID: 42290138 -
Autophagy
Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria. [Abstract]2026 May 25. PMID: 42186185 -
Nat Commun
CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cells. [Abstract]2026 Jun 9;17(1):5072. PMID: 42265110 -
Nat Commun
Sensight enables quantitative multivariate engineering of high-performance chemical imaging tools. [Abstract]2026 Jan 27;17(1):2061. PMID: 41593056 -
Nat Commun
Leveraging engineered mitochondria through intercellular communication network for accelerated transport and delivery. [Abstract]2025 Dec 23. PMID: 41436474 -
Nat Commun
Remodeling adipocytes' lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow. [Abstract]2025 Aug 27;16(1):8009. PMID: 40866384 -
Nat Commun
Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles' antifungal activities. [Abstract]2025 Jul 24;16(1):6821. PMID: 40707518 -
Nat Commun
VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis. [Abstract]2025 Jan 29;16(1):1160. PMID: 39880844 -
ACS Nano
Combinatorial Design of Fatty Acid-Incorporated Plasmid Lipid Nanoparticles Drives Dendritic Cell Hyperactivation for Enhanced Cancer Immunotherapy. [Abstract]2026 May 5;20(17):13196-13212. PMID: 42003370 -
ACS Nano
An Immunomodulating Regenerating Hydrogel That Rescues the Oxidative Microenvironment and Reverses Cell Senescence for Osteoporotic Bone Defects. [Abstract]2025 Aug 12;19(31):28353-28371. PMID: 40754989 -
ACS Nano
ZnO Nanoparticle Exposure Disrupted Iron-Sulfur Protein Functions to Increase Macrophage Erythrophagocytosis and Disturb Systemic Iron Recycling. [Abstract]2025 May 20;19(19):18450-18465. PMID: 40333237 -
ACS Nano
2025 Jan 21;19(2):2695-2714. PMID: 39787443 -
J Adv Res
miR-7480-5p/SIRT3/GSH axis mediates selenium Deficiency-Exacerbated trimethyltin chloride-induced ferroptosis in chicken thymus. [Abstract]2026 Mar 20:S2090-1232(26)00264-X. PMID: 41865790 -
J Adv Res
A novel mechanism of selenium deficiency driving aberrant Th17 cell differentiation via GPX3-targeted PIG3: mitophagy blockade exacerbates mtDNA release. [Abstract]2026 Feb 21:S2090-1232(26)00175-X. PMID: 41730416 -
J Adv Res
MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis. [Abstract]2025 Oct 10:S2090-1232(25)00764-7. PMID: 41077348 -
Redox Biol
Mitochondrial OXPHOS integrates immunometabolic cascade for bone regeneration via coupled ATP production and ROS homeostasis. [Abstract]2026 Jun 22:95:104272. PMID: 42335846 -
Redox Biol
TRPV4 drives macrophage pyroptosis via mitochondrial dysfunction and mtROS-dependent NLRP3 inflammasome activation in acute lung injury. [Abstract]2026 Jun 11:95:104255. PMID: 42314332 -
Redox Biol
Redox compartmentalization drives functional heterogeneity of mature insulin secretory vesicles in pancreatic β-cells. [Abstract]2025 Oct:86:103847. PMID: 40902318 -
Redox Biol
Artesunate induces ferroptosis in gastric cancer by targeting the TFRC-HSPA9 axis for iron homeostasis regulation. [Abstract]2025 Sep 10:87:103867. PMID: 40946428 -
Redox Biol
Lipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes. [Abstract]2024 Jul:73:103143. PMID: 38754271
MitoSOX Red purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jul:73:103143. [Abstract]
Results of incubation with the JC-1 fluorescent probe, FerroOrange probe, DCFH-DA, MitoSOX Red (5 μM; 30 min).
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Redox Biol
Breast cancer cells have an increased ferroptosis risk induced by system xc- blockade after deliberately downregulating CYTL1 to mediate malignancy. [Abstract]2024 Apr:70:103034. PMID: 38211443 -
Redox Biol
Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction. [Abstract]2024 Jun:72:103129. PMID: 38574433 -
J Nanobiotechnology
Engineered neuronal exosomes mediate α-synuclein clearance to ameliorate Parkinson's disease. [Abstract]2026 May 23. PMID: 42177528 -
J Nanobiotechnology
Porphyromonas gingivalis extracellular vesicles exacerbated osteoporosis by disrupting osteoblast mitochondrial dynamics and inhibiting Cpt2-regulated fatty acid oxidation. [Abstract]2025 Oct 10;23(1):635. PMID: 41074134 -
J Nanobiotechnology
Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics. [Abstract]2024 Sep 5;22(1):543. PMID: 39238005 -
J Nanobiotechnology
Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin. [Abstract]2024 Mar 25;22(1):129. PMID: 38528554
MitoSOX Red purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Mar 25;22(1):129. [Abstract]
MitoSOX Red (10 μM; 30 min). Mitochondrial superoxide levels by MitoSOX Red fluorescent staining with MFI quantification. (G&H) Mitochondrial membrane potential by JC-1 staining with calculation of the ratio of red MFI (aggregated JC-1) to green MFI (monomer JC-1).
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J Exp Clin Cancer Res
Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2. [Abstract]2025 Aug 9;44(1):232. PMID: 40781716 -
J Exp Clin Cancer Res
M2 macrophage-secreted KYNU promotes stemness remodeling and malignant behavior in endometrial cancer via the SOD2-mtROS-ERO1α-UPRER axis. [Abstract]2025 Jul 4;44(1):193. PMID: 40616124 -
J Exp Clin Cancer Res
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway. [Abstract]2024 Dec 26;43(1):330. PMID: 39721999 -
Adv Sci (Weinh)
Herba Lysimachiae Polysaccharide-Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22-Regulated Mitophagy Activation. [Abstract]2026 May 19:e75784. PMID: 42154455 -
Adv Sci (Weinh)
CircTspan3 Promotes Cartilage Development Through ANNEXIN A2-Mediated Ferroptosis and Apoptosis Inhibition and Exosome-Mediated Paracrine Signaling. [Abstract]2026 Feb;13(10):e13418. PMID: 41486887 -
Adv Sci (Weinh)
Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction. [Abstract]2025 Jun;12(22):e2407446. PMID: 40089865 -
Biomaterials
A biocompatible copper based therapeutic nanoplatform for CD44 specific tumor targeted therapy and potent immune reprogramming. [Abstract]2026 Jun 13:335:124373. PMID: 42314235 -
Cell Death Differ
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy. [Abstract]2025 Sep 23. PMID: 40987895 -
Biomaterials
Sonodynamic amplification of cGAS-STING activation by cobalt-based nanoagonist against bone and metastatic tumor. [Abstract]2023 Nov:302:122295. PMID: 37666101
MitoSOX Red purchased from MedChemExpress. Usage Cited in: Biomaterials. 2023 Nov:302:122295. [Abstract]
Representative fluorescent images of MitoSOX Red (30 min) in 4T1and LLC cells.
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Research (Wash D C)
2025 Jun 25:8:0860. PMID: 40862056 -
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MitoSOX Red purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2024 Oct 15.
MitoSOX Red (5 µM). Mitochondrial ROS in H2O2-stimulated fibroblasts incubated with different hydrogels, assessed by DCFH-DA and MitoSOX staining, respectively.
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J Control Release
Implantable piezocatalytic enzyme hydrogel re-engineers metabolic reprogramming for ischemic stroke therapy. [Abstract]2026 Jun 10:394:114866. PMID: 41895532 -
Pharmacol Res
ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction. [Abstract]2025 Dec:222:108029. PMID: 41205728 -
Cell Mol Biol Lett
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis. [Abstract]2025 Jul 28;30(1):93. PMID: 40722060 -
Cell Death Dis
SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury. [Abstract]2025 Apr 1;16(1):232. PMID: 40169535 -
Cell Death Dis
2024 Nov 1;15(11):786. PMID: 39487118 -
Cell Death Dis
Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolism. [Abstract]2024 Sep 4;15(9):650. PMID: 39231943 -
Cell Mol Biol Lett
APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling. [Abstract]2024 Jun 12;29(1):87. PMID: 38867189 -
Small
NIR-II Absorbed Dithienopyrrole-Benzobisthiadiazole Based Nanosystems for Autophagy Inhibition and Calcium Overload Enhanced Photothermal Therapy. [Abstract]2024 Sep;20(37):e2309891. PMID: 38721972
MitoSOX Red purchased from MedChemExpress. Usage Cited in: Small. 2024 Sep;20(37):e2309891. [Abstract]
CLSM images of changes in ROS in mitochondria of HOS cells treated with different groups.
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J Immunother Cancer
Dual roles of IRE1α inhibition in reversing mitochondrial ROS-induced CD8+ T-cell senescence and exerting direct antitumor effects in multiple myeloma. [Abstract]2025 May 26;13(5):e011044. PMID: 40425229 -
Int J Biol Sci
Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy. [Abstract]2023 Mar 21;19(6):1831-1845. PMID: 37063418 -
Cell Commun Signal
Regulatory role of sirtuin-1 by targeting MDM2 to mitochondria-associated membranes formation in the treatment of NAFLD. [Abstract]2025 Nov 28;23(1):514. PMID: 41316250 -
Cell Commun Signal
Mechanistic insights into targeting APLN/APJ for ameliorating testosterone deficiency and reproductive disorders in diabetic mice. [Abstract]2025 Oct 30;23(1):469. PMID: 41168800 -
Cell Commun Signal
Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway. [Abstract]2024 Nov 26;22(1):566. PMID: 39587603 -
Phytomedicine
Mollugin induces ferroptosis through dysregulation of iron homeostasis and redox balance in non-small cell lung cancer. [Abstract]2026 Jul 25:157:158316. PMID: 42241811 -
Phytomedicine
Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway. [Abstract]2026 Jun:155:158126. PMID: 41931998 -
Phytomedicine
Xuebijing injection alleviates sepsis-induced acute lung injury by triggering ferroptosis of CCR2hi monocytes. [Abstract]2026 Jan:150:157641. PMID: 41365193 -
Phytomedicine
Anti-tumor effects of Guggulsterone in osteosarcoma: Role of SIRT3-mediated PINK1-Parkin mitophagy activation. [Abstract]2026 Jan 20:153:157860. PMID: 41650525 -
Phytomedicine
Naringenin alleviates endotoxin-induced acute kidney injury in chicken by inhibiting pyroptosis through PINK1-dependent mitophagy. [Abstract]2025 Dec:149:157429. PMID: 41297318 -
Phytomedicine
Z-Ligustilide's antidepressant effects in adolescent depression involve the PTEN-induced putative kinase 1 (PINK1) - protein kinase A (PKA)- Na+/Ca2+ exchanger (NCLX) pathway, facilitating mitochondrial endosymbiosis and promoting mitophagy in microglia. [Abstract]2025 Dec:149:157494. PMID: 41218379 -
Phytomedicine
Kaempferol attenuated LPS-induced microglial neurotoxicity by promoting mitophagy to inhibit mtDNA-mediated NLRP3 inflammasome activation. [Abstract]2025 Nov 25:148:157486. PMID: 41202376 -
Phytomedicine
Cycloastragenol reduces microglial NLRP3 inflammasome activation in Parkinson's disease models by promoting autophagy and reducing Scrib-driven ROS. [Abstract]2024 Dec:135:156210. PMID: 39522252 -
Phytomedicine
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway. [Abstract]2024 Dec:135:156143. PMID: 39461200 -
Adv Healthc Mater
2026 Jun;15(22):e05925. PMID: 41964318 -
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Adv Healthc Mater
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function. [Abstract]2025 Mar;14(7):e2404319. PMID: 39831810 -
Mater Today Bio
Thermosensitive injectable in situ forming hydrogel incorporating anti-oxidative stress and anti-inflammatory nanoparticles for vital pulp therapy of pulpitis. [Abstract]2025 Jan 23:31:101482. PMID: 39944531 -
Adv Healthc Mater
A Non-Metallic Nanozyme Ameliorates Pulmonary Hypertension Through Inhibiting ROS/TGF-β1 Signaling. [Abstract]2024 Dec;13(30):e2401909. PMID: 39155419
MitoSOX Red purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2024 Dec;13(30):e2401909. [Abstract]
MitoSOX Red (5 μM; 30 min). Mitochondrial ROS detected by Mito-SOX RED in control and MCT-PASMCs with or without MPP nanoparticles. Scale bar: 100 µm.
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Adv Healthc Mater
Hydrogel Microsphere-Encapsulated Bimetallic Nanozyme for Promoting Diabetic Bone Regeneration via Glucose Consumption and ROS Scavenging. [Abstract]2024 Dec;13(32):e2402596. PMID: 39252661 -
Mater Today Bio
Melatonin-loaded bioactive microspheres accelerate aged bone regeneration by formation of tunneling nanotubes to enhance mitochondrial transfer. [Abstract]2024 Aug 2:28:101175. PMID: 39171100 -
Arch Toxicol
Oxidative stress-mediated DNA fragmentation involved in STING-dependent apoptosis in human keratinocytes by 5-amino-2-methylphenol under ambient UVB exposure. [Abstract]2026 Mar 10. PMID: 41807792 -
J Hazard Mater
Polystyrene and polyvinyl chloride microplastics exposure induces ocular surface inflammation by causing mitochondrial damage and lipid metabolic disruption. [Abstract]2026 Jan 15:502:140995. PMID: 41499868 -
J Hazard Mater
2025 Oct 5:497:139793. PMID: 40925161 -
J Hazard Mater
Effect of oxidative stress induced by 2,3,7,8- tetrachlorodibenzo-p-dioxin on DNA damage. [Abstract]2024 Jul 5:472:134485. PMID: 38701725 -
J Hazard Mater
SKN-1/Nrf2-dependent regulation of mitochondrial homeostasis modulates transgenerational toxicity induced by nanoplastics with different surface charges in Caenorhabditis elegans. [Abstract]2023 Sep 5:457:131840. PMID: 37327611
MitoSOX Red purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2023 Sep 5:457:131840. [Abstract]
Representative images of MitoSOX Red (100 nM; 2 h)-staining in P0C. elegans after nanoplastic exposure with different surface charges.
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J Orthop Translat
Talin1 loss activates DRG neurons to accelerate bone remodeling and fracture healing in mice. [Abstract]2026 May 8:58:101113. PMID: 42169959 -
NPJ Sci Food
Hydroxytyrosol attenuates obesity-induced myocardial fibrosis by inhibiting NLRP3/CYLD/NOX4 mediated oxidative stress. [Abstract]2026 May 30. PMID: 42225718 -
J Transl Med
GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux. [Abstract]2025 Oct 31;23(1):1202. PMID: 41174669 -
J Transl Med
Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke. [Abstract]2025 Apr 5;23(1):402. PMID: 40188077 -
J Transl Med
S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation. [Abstract]2024 Jun 5;22(1):535. PMID: 38840216 -
J Transl Med
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx. [Abstract]2024 Apr 4;22(1):332. PMID: 38575957 -
J Colloid Interface Sci
Molecularly imprinted nanoparticles hitchhiking on neutrophils for precise treatment of ischemic stroke. [Abstract]2025 Jul:689:137246. PMID: 40056670 -
Int J Biol Macromol
Hyaluronic acid-based responsive hydrogel with sequential drug release: targeting oxidative stress and angiogenesis to accelerate diabetic wound healing. [Abstract]2026 May:360:151953. PMID: 41966380 -
Int J Biol Macromol
Targeting OXCT1 with the methyl donor S-adenosylmethionine as a therapeutic strategy for cerebral cavernous malformations. [Abstract]2026 Apr:355:151129. PMID: 41865434 -
Int J Biol Macromol
Lipocalin 2 deficiency attenuates NLRP3 inflammasome activation through glycolysis impairment and MGST1-mediated mitochondrial ROS reduction. [Abstract]2025 Dec;334(Pt 1):149021. PMID: 41260431 -
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Int J Biol Macromol
Peroxisome proliferator-activated receptor gamma (PPARγ) promotes the morula-to-blastocyst transition in Tibetan sheep embryos by enhancing mitophagy through suppression of the AKT/mTOR pathway. [Abstract]2025 Oct 17;331(Pt 2):148371. PMID: 41110574 -
Int J Biol Macromol
Low molecular weight protein tyrosine phosphatase: A driver of lipid metabolic remodeling in Caenorhabditis elegans. [Abstract]2025 May;306(Pt 1):141332. PMID: 39988157 -
Int J Biol Macromol
2025 May;307(Pt 3):141976. PMID: 40086544 -
Int J Biol Macromol
Single-organelle visualization tracking natural glycosaminoglycans within mitochondria-lysosome crosstalk for inflammatory homeostasis. [Abstract]2025 Apr:303:140362. PMID: 39880268 -
Int J Nanomedicine
Nano Acacetin Mitigates Intestinal Mucosal Injury in Sepsis Rats by Protecting Mitochondrial Function and Regulating TRX1 to Inhibit the NLRP3 Pyroptosis Pathway. [Abstract]2024 Dec 31:19:14125-14141. PMID: 39759963 -
Int J Biol Macromol
Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2/HO-1 pathway in mouse hippocampal neurons. [Abstract]2023 Nov 1:251:126315. PMID: 37582438 -
Int J Mol Med
Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis. [Abstract]2026 Aug;58(2):217. PMID: 42272256 -
Int J Mol Med
Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer. [Abstract]2026 Jan;57(1):4. PMID: 41133455 -
Mol Med
Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis. [Abstract]2025 Aug 2;31(1):272. PMID: 40753437 -
Mol Med
Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission. [Abstract]2024 Oct 10;30(1):173. PMID: 39390372 -
Antioxidants (Basel)
5-Aminolevulinic Acid-Mediated Photodynamic Therapy Induces Ferroptosis in Oral Leukoplakia and Oral Squamous Cell Carcinoma. [Abstract]2026 Jan 26;15(2):167. PMID: 41750549 -
Antioxidants (Basel)
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]2024 May 29;13(6):667. PMID: 38929106 -
Phytother Res
Vitexin Alleviates Osteoarthritis Progression Through Sirtuin 3-Mediated Inhibition of Chondrocyte Ferroptosis and Mitochondrial Dysfunction. [Abstract]2026 Jun 22. PMID: 42333683 -
Phytother Res
Pogostone Suppresses Microglial NLRP3 Inflammasome Activation-Promoted Remyelination Through RXRγ Regulation of Mitophagy. [Abstract]2026 May;40(5):2844-2861. PMID: 41801318 -
Phytother Res
Glycyrrhiza Uralensis Fisch. Alleviates Paraquat-Induced Lung Injury by Repairing Mitochondrial Respiratory Chain Dysfunction. [Abstract]2026 Apr;40(4):1735-1749. PMID: 41618623 -
Phytother Res
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway. [Abstract]2025 May 26. PMID: 40415605 -
Phytother Res
Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK-ULK1-FUNDC1 Signaling Pathway. [Abstract]2025 May;39(5):2393-2406. PMID: 40190139 -
Free Radic Biol Med
Antiandrogen therapy induces mitochondrial oxidative phosphorylation to promote castration resistance in prostate cancer. [Abstract]2026 Sep:253:463-477. PMID: 42219062 -
Free Radic Biol Med
SESN2 suppresses ferroptosis in polycystic ovary syndrome by maintaining PRDX6 K209 lactylation. [Abstract]2026 Aug 1:251:75-90. PMID: 41966311 -
Free Radic Biol Med
TSPO integrates redox and immune homeostasis in dermal fibroblasts to restrain vitiligo pathogenesis. [Abstract]2026 Aug 16:252:214-226. PMID: 42097319 -
Free Radic Biol Med
CAND1 drives intestinal ischemia/reperfusion injury via SCFFBXO6-PKM2-mediated mitochondrial fission and apoptosis. [Abstract]2026 Jun 15:254:181-195. PMID: 42297194 -
Free Radic Biol Med
DRP1-mediated mitophagy facilitates oral squamous cell carcinoma tumor cell survival under glucose restriction. [Abstract]2026 Jun 27:254:391-404. PMID: 42364552 -
Free Radic Biol Med
IL-6/STAT3 signaling drives mitochondrial oxidative phosphorylation dysfunction and AP-1 activation in fibroblasts during sepsis-induced lung injury. [Abstract]2026 May 26:253:148-163. PMID: 42191040 -
Free Radic Biol Med
FXR overexpression restores NLRP3-mediated mitophagy and improves mitochondrial dysfunction in alcoholic liver disease. [Abstract]2026 Apr:247:173-186. PMID: 41662916 -
Free Radic Biol Med
Taurine restores oocyte quality by enhancing mitochondrial function in mice exposed to dibutyl phthalate during adolescence. [Abstract]2026 Apr:247:224-239. PMID: 41651302 -
Free Radic Biol Med
Myeloperoxidase (MPO) mediates LPS-induced mitophagy in murine macrophages through AMPK/ULK1 pathway. [Abstract]2026 Apr 21:251:333-346. PMID: 42025704 -
Free Radic Biol Med
HO-1/Nrf2 activation orchestrates protection in sepsis-induced lung injury by suppressing CCR2hi monocyte recruitment and MAPK-driven inflammation. [Abstract]2026 Apr:247:122-138. PMID: 41651304 -
Free Radic Biol Med
DECR1 deficiency activates a lipid peroxidation-mitocytosis-mitochondrial dysfunction axis in trophoblasts to promote preeclampsia. [Abstract]2026 Mar 18:250:1-15. PMID: 41862008 -
Free Radic Biol Med
LINC03047 promotes mitophagy by recruiting hnRNPF to enhance CTGF mRNA stability in hypoxic pulmonary hypertension. [Abstract]2026 Feb 1:243:111-125. PMID: 41232621 -
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Free Radic Biol Med
TRAF6 mediates vascular remodeling via endoplasmic reticulum stress-mitophagy in hypoxic pulmonary hypertension. [Abstract]2025 Dec 20:245:237-249. PMID: 41429276 -
Free Radic Biol Med
HPCAL1-BNIP3 axis promotes mitophagy-ferroptosis feedback loop that exacerbates intestinal ischemia-reperfusion injury. [Abstract]2025 Dec 31:245:223-236. PMID: 41482082 -
Free Radic Biol Med
MiRNA-122-5p promotes retinal ganglion cell oxidative damage by targeting DJ-1 in hyperglycemic retina. [Abstract]2025 Nov:239:352-366. PMID: 40759398 -
Free Radic Biol Med
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation. [Abstract]2025 Jun 14:237:585-599. PMID: 40518125 -
Free Radic Biol Med
Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium. [Abstract]2025 Feb 16:228:173-182. PMID: 39761766 -
Free Radic Biol Med
Ceramide synthase 6 induces mitochondrial dysfunction and apoptosis in hemin-treated neurons by impairing mitophagy through interacting with sequestosome 1. [Abstract]2025 Feb 1:227:282-295. PMID: 39643132 -
Free Radic Biol Med
Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 / PINK 1-Parkin / EMT. [Abstract]2024 Nov 1:224:447-456. PMID: 39214258 -
Free Radic Biol Med
Knocking down EGR1 inhibits nucleus pulposus cell senescence and mitochondrial damage through activation of PINK1-Parkin dependent mitophagy, thereby delaying intervertebral disc degeneration. [Abstract]2024 Nov 1:224:9-22. PMID: 39151834 -
Free Radic Biol Med
Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair. [Abstract]2024 Nov 20:225:164-180. PMID: 39343182 -
Free Radic Biol Med
SGLT1 inhibition alleviates radiation-induced intestinal damage through promoting mitochondrial homeostasis. [Abstract]2024 Nov 1:224:831-845. PMID: 39393555 -
Free Radic Biol Med
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation. [Abstract]2024 Aug 1:220:15-27. PMID: 38679301 -
Free Radic Biol Med
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma. [Abstract]2024 Aug 1:220:111-124. PMID: 38697493 -
J Genet Genomics
SYMPK interacts with KIF20A and NUMA1 to coordinate spindle organization and safeguard oocyte meiotic maturation. [Abstract]2026 Jan 9:S1673-8527(26)00002-0. PMID: 41520922 -
J Anim Sci Biotechnol
Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10. [Abstract]2025 May 24;16(1):74. PMID: 40410809 -
ACS Appl Mater Interfaces
Graphene Oxide Quantum Dots-Loaded Extracellular Vesicles with Inflamed Pulp-Homing Targeting Enhance Pulp Repair in Pulpitis by Upregulating Glycolysis. [Abstract]2026 May 27. PMID: 42202129 -
ACS Appl Mater Interfaces
Three-Dimensional Printed Photo-Cross-Linked Gelatin Methacrylate Hydrogel Scaffold-Incorporated Mitochondria-Targeted Hydrogen Sulfide Donor-Loaded Liposomes for Spinal Cord Injury Repair. [Abstract]2026 Mar 11;18(9):13420-13436. PMID: 41758638 -
ACS Appl Mater Interfaces
Mitochondrial-Targeting Drug-Loaded Nanoparticles Reprogram Macrophage Metabolism via ROS/NO Co-elimination for Diabetic Wound Healing. [Abstract]2025 Dec 24;17(51):69180-69195. PMID: 41383171 -
ACS Appl Mater Interfaces
Cerium-Organic Framework and Resveratrol Composite Hydrogel Scaffold with Dual Antioxidant Activity for Enhanced Bone Regeneration. [Abstract]2025 Jun 4;17(22):31828-31842. PMID: 40401746 -
Br J Cancer
Repurposing chlorpromazine for the treatment of triple-negative breast cancer growth and metastasis based on modulation of mitochondria-mediated apoptosis and autophagy/mitophagy. [Abstract]2025 Apr 11. PMID: 40217096 -
Stem Cell Res Ther
FAM96B negatively regulates FOSL1 to modulate the osteogenic differentiation and regeneration of periodontal ligament stem cells via ferroptosis. [Abstract]2024 Dec 18;15(1):471. PMID: 39696611 -
Aging Cell
Senescent BMSC-Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin-Mediated Mitophagy in Macrophages. [Abstract]2026 Jun;25(6):e70575. PMID: 42257494 -
Cell Rep
2026 Jun 9;45(6):117515. PMID: 42268710 -
Cell Rep
2026 Mar 27;45(4):117183. PMID: 41903135 -
Aging Cell
2025 Feb;24(2):e14391. PMID: 39473192 -
Cell Rep
Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes. [Abstract]2024 Jan 3;43(1):113658. PMID: 38175755 -
Brain Behav Immun
2026 May 19:137:106821. PMID: 42162806 -
J Pineal Res
Melatonin Protects Mouse Oocytes From the Environmental Toxicant 6PPD-Quinone by Preserving Mitochondrial and Endomembrane Homeostasis. [Abstract]2026 Mar;78(2):e70133. PMID: 41823979 -
Brain Behav Immun
IL-17A-mediated copper accumulation participates in chronic neuropathic pain-induced cognitive impairment by enhancing microglial synaptic pruning. [Abstract]2026 Feb:132:106208. PMID: 41349925 -
Cell Mol Neurobiol
Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson's Disease. [Abstract]2025 May 29;45(1):53. PMID: 40439946 -
J Med Chem
Phytohormone Strigolactams Overcomes Oxaliplatin Resistance in Colorectal Cancer by Blocking the Late-Stage Autophagy to Tip the Metabolic Balance toward Ferroptosis. [Abstract]2025 Nov 27;68(22):24546-24559. PMID: 41208142 -
Int J Oncol
Norchelerythrine from Corydalis incisa (Thunb.) Pers. promotes differentiation and apoptosis by activating DNA damage response in acute myeloid leukemia. [Abstract]2025 Mar;66(3):17. PMID: 39918000 -
Environ Pollut
The endoplasmic reticulum-mitochondrial crosstalk involved in nanoplastics and di(2-ethylhexyl) phthalate co-exposure induced the damage to mouse mammary epithelial cells. [Abstract]2025 May 1:372:126014. PMID: 40057162 -
Environ Pollut
AHR/cyp1b1 signaling-mediated extrinsic apoptosis contributes to 6PPDQ-induced cardiac dysfunction in zebrafish embryos. [Abstract]2024 Mar 15:345:123467. PMID: 38311157 -
Redox Rep
Urolithin A alleviates vascular remodeling through mitochondrial SIRT3-mediated SOD2 deacetylation and antioxidation in hypertensive rats. [Abstract]2026 Dec;31(1):2622255. PMID: 41645805 -
Redox Rep
ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis. [Abstract]2025 Dec;30(1):2536400. PMID: 40691128 -
J Ethnopharmacol
Sanhuang Xiexin decoction ameliorates acute lung injury by disrupting NEK7-NLRP3 inflammasome activation. [Abstract]2026 Jul 15:366:121624. PMID: 41935649 -
J Ethnopharmacol
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2. [Abstract]2026 Mar 25:359:121067. PMID: 41419044 -
J Ethnopharmacol
Shentong Zhuyu Decoction mitigates exercise-induced muscle damage through modulation of AMPK-mediated lipid metabolism and oxidative stress. [Abstract]2026 Feb 28:357:120941. PMID: 41270908 -
J Ethnopharmacol
Kai-Xin-San alleviates Alzheimer's disease by targeting the DHFR-mediated folate-mitochondrial axis. [Abstract]2026 Apr 24:361:121230. PMID: 41548619 -
Antioxid Redox Signal
2025 Feb;42(4-6):184-198. PMID: 39001814 -
J Agric Food Chem
Lycopene Prevents DEHP-Induced Ferroptosis in Cerebellar Microglia by Regulating the PEBP1/ALOX15 Axis. [Abstract]2026 Jan 28;74(3):3040-3052. PMID: 41528317 -
Biomater Adv
Novel Ce/Cu-modified black ceramics disrupted mitochondrial dysfunction and tricarboxylic acid cycle to induce cuproptosis in osteosarcoma cells. [Abstract]2026 Mar:180:214576. PMID: 41218466 -
NanoImpact
CdTe quantum dots induce apoptosis in RSC96 cells by disrupting calcium homeostasis and triggering subcellular structural dysfunction. [Abstract]2025 Jul:39:100572. PMID: 40527434 -
J Agric Food Chem
Apigenin-Mediated ESCRT-III Activation and Mitophagy Alleviate LPS-Induced Necroptosis in Renal Cells. [Abstract]2025 Apr 10. PMID: 40211127 -
J Agric Food Chem
TNF/TNFR1 Signaling Mediates DEHP-Induced Hepatocyte Pyroptosis via the GSDMD-mtROS Axis. [Abstract]2025 Mar 26;73(12):7432-7444. PMID: 39999303 -
CNS Neurosci Ther
Zinc Overload in Microvessels Contributes to Blood-Brain Barrier Disruption by Activating the JAK2 Pathway After Cerebral Ischemia/Reperfusion. [Abstract]2026 Apr;32(4):e70885. PMID: 41989273 -
Ecotoxicol Environ Saf
Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models. [Abstract]2025 Sep 15:303:118920. PMID: 40886601 -
Ecotoxicol Environ Saf
Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells. [Abstract]2025 Apr 15:295:118139. PMID: 40185034 -
Ecotoxicol Environ Saf
BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function. [Abstract]2025 Jan 1:289:117693. PMID: 39788034 -
Ecotoxicol Environ Saf
MicroRNA-129-1-3p protects chicken granulosa cells from cadmium-induced apoptosis by down-regulating the MCU-mediated Ca2+ signaling pathway. [Abstract]2024 Jan 1:269:115906. PMID: 38176135 -
Biochem Pharmacol
Nitazoxanide cooperates with cytarabine to inhibit cytarabine-resistant acute myeloid leukemia progression via mitochondrial dysfunction and PLK1 suppression. [Abstract]2026 Jun 4;251(Pt 2):118122. PMID: 42248474 -
Cell Mol Life Sci
Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication. [Abstract]2025 Nov 14;82(1):406. PMID: 41236547 -
Biochem Pharmacol
Inhibition of METTL3 promotes mesangial cell mitophagy and attenuates glomerular damage by alleviating FOSL1 m6A modifications via IGF2BP2-dependent mechanisms. [Abstract]2025 Jun:236:116867. PMID: 40081768 -
Biochem Pharmacol
Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation. [Abstract]2025 Jun:236:116868. PMID: 40081766 -
Biochem Pharmacol
Empagliflozin attenuates renal damage in diabetic nephropathy by modulating mitochondrial quality control via Prdx3-PINK1 pathway. [Abstract]2025 May:235:116821. PMID: 39983849 -
Life Sci
Nuclear translocation of GPS2 promotes activation of hepatic stellate cells by fatty acid oxidation pathway. [Abstract]2026 Sep 15:401:124529. PMID: 42276358 -
Life Sci
Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway. [Abstract]2025 Mar 15:365:123452. PMID: 39923835 -
Food Funct
Lactoferrin protects against radiation-induced intestinal injury by regulating pyroptosis and mitophagy. [Abstract]2026 Jan 26;17(2):1045-1060. PMID: 41524100 -
Plant J
SGAM1 orchestrates salt tolerance by balancing mitochondrial translation and ROS homeostasis in Arabidopsis. [Abstract]2025 Jul;123(1):e70322. PMID: 40633123 -
Inflamm Res
Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis. [Abstract]2025 Jan 7;74(1):6. PMID: 39762437 -
-
RSC Adv
Gingerol-loaded hollow manganese dioxide nanoparticles attenuate intervertebral disc oxidative stress. [Abstract]2026 May 22;16(28):25447-25458. PMID: 42205673 -
Drug Des Devel Ther
Exploratory Study on the Role of Emodin in Alleviating MPTP-Induced Neurotoxicity: A Focus on p53-Ferroptosis Signaling. [Abstract]2025 Dec 1:19:10645-10660. PMID: 41356603 -
Cancer Immunol Immunother
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity. [Abstract]2025 Aug 25;74(9):293. PMID: 40853486 -
Commun Biol
Suppressing MTERF3 inhibits proliferation of human hepatocellular carcinoma via ROS-mediated p38 MAPK activation. [Abstract]2024 Jan 5;7(1):18. PMID: 38177713 -
Cell Biol Toxicol
HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity. [Abstract]2026 Feb 5;42(1):34. PMID: 41639490 -
Eur J Pharmacol
MPTP controls the release of mtDNA and induces endothelial cell PANoptosis in trichloroethylene-induced immune kidney injury. [Abstract]2025 Oct 15:1005:178118. PMID: 40912515 -
Mar Drugs
Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]2025 Mar 12;23(3):123. PMID: 40137309 -
Eur J Pharmacol
Taxifolin attenuates hepatic ischemia-reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy. [Abstract]2024 Dec 15:985:177100. PMID: 39542410 -
Int J Mol Sci
Metformin Alleviates Stress-Induced Premature Senescence of Vascular Endothelial Cells by Regulating Mitocytosis. [Abstract]2026 May 24;27(11):4724. PMID: 42278258 -
Int Immunopharmacol
Danggui Sini decoction attenuates intervertebral disc degeneration by regulating ferroptosis in nucleus pulposus cells via the GJA1/cGAS/STING signaling axis. [Abstract]2026 May 1:176:116458. PMID: 41812505 -
Int Immunopharmacol
Quercetin alleviates LPS-induced inflammation and immunosuppression in broiler spleen via regulating the mtDNA/cGAS/STING axis. [Abstract]2026 May 1:176:116482. PMID: 41797087 -
Int Immunopharmacol
Quercetin alleviates imatinib-induced premature ovarian insufficiency by regulating mitophagy via the ROS/JNK/c-JUN pathway. [Abstract]2026 Apr 15:175:116405. PMID: 41722539 -
Cell Oncol (Dordr)
Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux. [Abstract]2026 Jan 8;49(1):21. PMID: 41505038 -
Int Immunopharmacol
Mangiferin targeting HSP90α induces DNA damage in cutaneous squamous cell carcinoma via the ROS/MAPK signaling pathway. [Abstract]2026 Jan 1;168(Pt 2):115924. PMID: 41273839 -
Int J Mol Sci
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds. [Abstract]2025 Dec 12;26(24):11970. PMID: 41465397 -
Int J Mol Sci
Melatonin Rescues Heat Stress-Induced Suppression of TCA Cycle and Mitochondrial Damage in Goat Sertoli Cells. [Abstract]2025 Nov 27;26(23):11475. PMID: 41373630 -
Int J Mol Sci
2025 Sep 20;26(18):9185. PMID: 41009747 -
Int Immunopharmacol
Neutrophil extracellular traps activate STING signaling to promote dendritic cell-driven rejection after liver transplantation. [Abstract]2025 Jul 28:160:114763. PMID: 40449271 -
Int Immunopharmacol
Vaccarin alleviates renal ischemia-reperfusion injury by inhibiting inflammation and ferroptosis. [Abstract]2025 Apr 24:153:114463. PMID: 40112596 -
Int Immunopharmacol
Punicalagin inhibits neuron ferroptosis and secondary neuroinflammation to promote spinal cord injury recovery. [Abstract]2025 Feb 20:148:114048. PMID: 39823794 -
Biomolecules
2025 Feb 1;15(2):202. PMID: 40001505 -
ACS Appl Bio Mater
Ceria Nanoparticles Improve the Quality of Aging Oocytes in Mice by Enhancing ROS Scavenging Ability. [Abstract]2025 Feb 17;8(2):992-1001. PMID: 39957429 -
Int J Mol Sci
Therapeutic Potential of Adina rubella Hance Stem and Picroside III as a Differentiation Inducer in AML Cells via Mitochondrial ROS Accumulation. [Abstract]2025 Feb 5;26(3):1350. PMID: 39941121 -
Int Immunopharmacol
Perillaldehyde ameliorates lipopolysaccharide-induced acute lung injury via suppressing the cGAS/STING signaling pathway. [Abstract]2024 Mar 30:130:111641. PMID: 38368770 -
Int J Mol Sci
2023 Nov 25;24(23):16756. PMID: 38069081 -
Int J Mol Sci
In Vitro Transcriptional Response of Eimeria tenella to Toltrazuril Reveals That Oxidative Stress and Autophagy Contribute to Its Anticoccidial Effect. [Abstract]2023 May 6;24(9):8370. PMID: 37176073 -
Biol Direct
2026 Mar 23;21(1):57. PMID: 41872929 -
Invest Ophthalmol Vis Sci
DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN. [Abstract]2025 Jul 1;66(9):20. PMID: 40626806 -
Am J Physiol Cell Physiol
Interleukin-1β downregulates K+ currents through Kv1.6 channels and promotes apoptosis by enhancing Ca2+ influx in chondrocytes. [Abstract]2026 Mar 2. PMID: 41770339 -
Front Pharmacol
Selective anti-cancer effects of cannabidiol and Δ9-tetrahydrocannabinol via PI3K/AKT/mTOR inhibition and PTEN restoration in ovarian cancer cells. [Abstract]2025 Dec 15:16:1693129. PMID: 41472794 -
Biol Res
Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function. [Abstract]2024 Apr 1;57(1):13. PMID: 38561846 -
Chem Biol Interact
Co-exposure to PS-NPs and HFPO-TA potentiates reproductive toxicity via ferroptosis and SLC1A5-Mediated glutamine deprivation in male mice. [Abstract]2026 Jun 1:432:112059. PMID: 41887313 -
Toxicology
Hexafluoropropylene oxide homologues, the novel alternatives to PFOA, induce mitochondrial dysfunction and cytotoxicity in Leydig cells through disrupting SIRT1/PGC-1α signaling pathway. [Abstract]2025 Sep 17:154282. PMID: 40972997 -
Chem Biol Interact
Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells. [Abstract]2024 Apr 1:392:110904. PMID: 38360085 -
Exp Gerontol
Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2. [Abstract]2024 Aug:193:112468. PMID: 38801840 -
Exp Gerontol
PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway. [Abstract]2024 Jun 1:190:112428. PMID: 38604253 -
Biochim Biophys Acta Mol Basis Dis
Urolithin A protects against calcium oxalate-induced crystal formation and kidney injury by regulating PCK1 to restore mitophagy function in kidney stone disease. [Abstract]2025 Nov 19;1872(3):168106. PMID: 41265017 -
Biochim Biophys Acta Mol Basis Dis
PGC-1α role in rescuing ferroptosis in cerebral ischemia/reperfusion injury through promoting mitochondrial biogenesis and UCP2 expression. [Abstract]2025 Apr 26;1871(6):167874. PMID: 40294850 -
Ann Med
ESRRG downregulation in early spontaneous abortion induces mitochondrial damage, leading to impaired trophoblast function. [Abstract]2026 Dec;58(1):2622749. PMID: 41623023 -
PLoS Pathog
Glutamine alleviates Staphylococcus aureus-induced mastitis by modulating macrophage polarisation. [Abstract]2026 Mar 11;22(3):e1014053. PMID: 41811877 -
Sci Rep
Ubiquitin-specific protease 14 inhibition promotes mitophagy and attenuates neural apoptosis after spinal cord injury. [Abstract]2025 Dec 9;15(1):43741. PMID: 41366047 -
Sci Rep
Identification of potential biomarkers associated with mitochondrial oxidative stress in idiopathic pulmonary arterial hypertension via bioinformatic and experimental analysis. [Abstract]2025 Dec 9. PMID: 41365992 -
Cell Calcium
MICU1 attenuates neuronal apoptosis after subarachnoid hemorrhage by inhibiting mitochondrial calcium overload and damage. [Abstract]2025 Sep 14:132:103080. PMID: 40974956 -
Sci Rep
Circadian gene BMAL1 ameliorates renal ischaemia-reperfusion injury in diabetic mice by enhancing mitophagy via the HIF-1/BNIP3 pathway. [Abstract]2025 Jul 2;15(1):23001. PMID: 40594206 -
Sci Rep
Helium cold atmospheric pressure plasma reduces erastin induced inflammation and ferroptosis in human gingival fibroblasts. [Abstract]2025 Mar 3;15(1):7440. PMID: 40032893 -
J Mol Cell Cardiol
Cholesterol-induced HRD1 reduction accelerates vascular smooth muscle cell senescence via stimulation of endoplasmic reticulum stress-induced reactive oxygen species. [Abstract]2024 Feb:187:51-64. PMID: 38171043 -
Nanomaterials
Engineered Tan-CDs@AS-IV Nanosystem Orchestrates Mitochondrial Biogenesis and Intercellular Transfer to Restore Endothelial Function via PGC-1α and Cx43 Signaling Pathways. [Abstract]2026 Jun 4;16(11):698. PMID: 42274705 -
BMC Biotechnol
Mitochondria-targeted CORM-401 nanoparticles inhibit A549 cells by triggering cuproptosis. [Abstract]2026 Mar 31;26(1):64. PMID: 41917900 -
Exp Neurol
Inhibition of mitoNEET ameliorates traumatic brain injury-induced ferroptosis and cognitive dysfunction by stabilizing dihydroorotate dehydrogenase. [Abstract]2025 Jul:389:115235. PMID: 40189124 -
Neoplasia
MTFR1 phosphorylation-activated adaptive mitochondrial fusion is essential for colon cancer cell survival during glucose deprivation. [Abstract]2025 May:63:101159. PMID: 40121946 -
Eur J Med Res
Alcohol promotes CPT1A-induced lipid metabolism disorder to sentinel-regulate acute pancreatitis. [Abstract]2025 Jan 17;30(1):35. PMID: 39819476 -
Cell Signal
Ophiopogonis japonicus polysaccharide inhibits oxidative stress in hepatocytes by promoting Runx3 in nonalcoholic fatty liver disease. [Abstract]2026 Apr:140:112360. PMID: 41520744 -
Cell Signal
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells. [Abstract]2026 Feb:138:112221. PMID: 41205881 -
Cell Signal
Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS/STING signaling and Opa1-mediated mitochondrial fusion. [Abstract]2025 Aug:132:111805. PMID: 40246132 -
Cell Signal
PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney injury. [Abstract]2024 Sep:121:111282. PMID: 38971568 -
Biomedicines
Ferroptosis in Septic Cardiomyopathy Is Alleviated by Ondansetron: The Critical Role of the HTR3A-ATF3 Axis in Mitochondrial and Oxidative Homeostasis. [Abstract]2026 May 3;14(5):1040. PMID: 42193366 -
Brain Res Bull
Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway. [Abstract]2025 Jul:227:111404. PMID: 40441663 -
Bioengineering (Basel)
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells. [Abstract]2026 Feb 24;13(3):256. PMID: 41899787 -
Comp Biochem Physiol C Toxicol Pharmacol
Resveratrol attenuates trimethyltin chloride-induced cardiac defects via the ROS/Wnt/β-catenin pathway. [Abstract]2026 Jan:299:110373. PMID: 41083115 -
FASEB J
hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing. [Abstract]2026 Jan 31;40(2):e71445. PMID: 41524182 -
Biol Trace Elem Res
Activating PPARβ/δ-Mediated Fatty Acid β-Oxidation Mitigates Mitochondrial Dysfunction Co-induced by Environmentally Relevant Levels of Molybdenum and Cadmium in Duck Kidneys. [Abstract]2025 Jul;203(7):3870-3883. PMID: 39546187 -
FASEB J
Mitochondrial Genome-Encoded lncND5 Regulates Mitophagy in Hypoxic Pulmonary Artery Smooth Muscle Cell. [Abstract]2025 May 31;39(10):e70618. PMID: 40364724 -
Fish Shellfish Immunol
Aeromonas hydrophila induces mitophagy for intracellular survival through its secreted effectors in the splenic macrophages of grass carp (Ctenopharyngodon idella). [Abstract]2026 Jun:173:111248. PMID: 41786106 -
Front Biosci (Landmark Ed)
Tectorigenin Protects Irradiation-Induced Injury of HUVECs by Inhibiting Mitophagy Through PINK1/Parkin Pathway. [Abstract]2026 May 25;31(5):48938. PMID: 42216527 -
J Biol Chem
Neurofascin stabilization by contactin-associated protein-like 2 and CTCF alleviates mitochondrial dysfunction in Schwann cells during facial nerve injury. [Abstract]2025 Dec 22;302(2):111090. PMID: 41443418 -
Front Biosci (Landmark Ed)
2025 Jun 25;30(6):37052. PMID: 40613298 -
BMC Cancer
2025 Mar 6;25(1):412. PMID: 40050778 -
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Skelet Muscle
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice. [Abstract]2025 Jan 13;15(1):2. PMID: 39806512 -
Viruses
2025 Jun 30;17(7):930. PMID: 40733549 -
J Biochem Mol Toxicol
UCP2 in Glioblastoma Cells Regulates Mitochondrial Metabolic Reprogramming to Mediate Immunophenotypic Repolarization of Tumor-Associated Macrophages and Immunotherapy. [Abstract]2026 Apr;40(4):e70808. PMID: 41918143 -
Arch Med Res
Monocarboxylate Transporter 4 Inhibition Reduces Synovial Hyperproliferation and Metabolic Reprogramming Under Hypoxia in Rheumatoid Arthritis. [Abstract]2025 Aug 18;57(1):103283. PMID: 40829205 -
Toxicol Appl Pharmacol
The resveratrol attenuates reactive oxygen species mediated DNA damage in cardiac malformations caused by 4-tert-octylphenol. [Abstract]2025 May:498:117284. PMID: 40023230 -
J Biochem Mol Toxicol
Apelin-13 Protects Against Myocardial Hypoxia/Reoxygenation (H/R) Injury by Inhibiting Ferroptosis Via Nrf2 Activation. [Abstract]2025 Apr;39(4):e70223. PMID: 40152053 -
Exp Cell Res
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity. [Abstract]2025 Apr 15;447(2):114517. PMID: 40089133 -
J Neurooncol
Mifepristone achieves tumor suppression and ferroptosis through PR/p53/HO1/GPX4 axis in meningioma cells. [Abstract]2025 Apr;172(2):377-386. PMID: 39751705 -
Biol Reprod
Age-dependent testicular autophagy disruption mediates juvenile susceptibility to dibutyl phthalate-induced reproductive toxicity. [Abstract]2026 Jun 9:ioag120. PMID: 42262418 -
Biol Reprod
O-GlcNAcylation of p66Shc drives senescence associated secretory phenotype via mitochondrial DNA release in gestational diabetes mellitus†. [Abstract]2026 May 11:ioag090. PMID: 42113624 -
J Diabetes Complications
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress. [Abstract]2025 Dec 13;40(2):109250. PMID: 41411956 -
Mol Biol Rep
Peroxiredoxin II exerts neuroprotective effects by inhibiting endoplasmic reticulum stress and oxidative stress-induced neuronal pyroptosis. [Abstract]2024 May 5;51(1):607. PMID: 38704801 -
Animals (Basel)
Quercetin Alleviates Toxicity Induced by High Levels of Copper in Porcine Follicular Granulosa Cells by Scavenging Reactive Oxygen Species and Improving Mitochondrial Function. [Abstract]2023 Aug 29;13(17):2745. PMID: 37685009 -
Exp Eye Res
SIRT3 mediates mitochondrial protection and attenuates mtROS-TXNIP-NLRP3 signaling activation in dry eye disease. [Abstract]2026 Jun:267:110960. PMID: 41791477 -
Oral Dis
2025 Feb;31(2):577-588. PMID: 39054859 -
Exp Eye Res
Rosmarinic acid alleviates fungal keratitis caused by Aspergillus fumigatus by inducing macrophage autophagy. [Abstract]2024 Jul:244:109944. PMID: 38797260 -
Hear Res
Susceptibility of immature spiral ganglion neurons to aminoglycoside-induced ototoxicity is mediated by the TRPV1 channel in mice. [Abstract]2023 Dec:440:108910. PMID: 37956582 -
Phytochem Anal
2026 Jan 20. PMID: 41559525 -
Fitoterapia
Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers. [Abstract]2025 Jul:184:106627. PMID: 40381851 -
Toxicol Res (Camb)
Dexamethasone-induced mitochondrial ROS-mediated inhibition of AMPK activity facilitates osteoblast necroptosis. [Abstract]2023 Sep 23;12(5):922-929. PMID: 37915480 -
Toxicol In Vitro
Triphenyltin chloride exposure inhibits meiotic maturation of mouse oocytes by disrupting cytoskeleton assembly and cell cycle progression. [Abstract]2024 Jun:98:105834. PMID: 38657713 -
Urolithiasis
Calcium oxalate crystals exacerbate the damage and inflammation of renal tubular epithelial cells by blocking autophagic flux. [Abstract]2026 Apr 6;54(1):82. PMID: 41940969 -
J Nat Med
Ginsenoside Rh3-induced neurotoxicity involving the IP3R-Ca2+/NOX2/NF-κB signaling pathways. [Abstract]2025 Jul;79(4):791-806. PMID: 40360886 -
Clin Exp Pharmacol Physiol
Ciliatoside A Improves Klebsiella pneumoniae-Induced Pneumonia by Modulating Mitochondrial Autophagy via the SIRT1/PINK1/Parkin Pathway. [Abstract]2026 May;53(5):e70125. PMID: 42026873 -
J Clin Lab Anal
Ginsenoside Rb1 Targets the HRD1-STING Axis to Mitigate Cholesterol-Induced VSMC Senescence. [Abstract]2026 Mar;40(5):e70172. PMID: 41626813 -
Biochem Biophys Res Commun
Antioxidant defense response mediated by DAF-16 attenuates toxicity of herbicides glyphosate and glufosinate ammonium on Caenorhabditis elegans. [Abstract]2025 Apr 5:756:151577. PMID: 40056504 -
J Mol Neurosci
Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes. [Abstract]2025 Feb 17;75(1):23. PMID: 39961873 -
Dev Comp Immunol
2025 Jan:162:105295. PMID: 39613199 -
Exp Ther Med
Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress. [Abstract]2024 Mar 26;27(5):226. PMID: 38596659 -
Leuk Lymphoma
Homoharringtonine sensitized resistant acute myeloid leukemia cells to venetoclax-induced apoptosis. [Abstract]2024 Dec;65(14):2138-2150. PMID: 39235111 -
Genes Genomics
2025 Nov 26. PMID: 41296171 -
Xenobiotica
Beta-aminoisobutyric acid attenuates doxorubicin-induced cardiotoxicity through the adenosine 5'-monophosphate-activated protein kinase-mediated pathway. [Abstract]2025 May;55(5):436-443. PMID: 40525744 -
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Res Sq
TET1 Protects the Lungs from Diesel Exhaust Particle-Induced Inflammation and Abnormal Function. [Abstract]2026 Jun 19:rs.3.rs-9860246. PMID: 42370274 -
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bioRxiv
ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma. [Abstract]2025 Sep 4:2025.09.02.671886. PMID: 40950224 -
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Biomed Pharmacother
Azvudine exhibits potent differentiation-inducing effect by targeting the TERT/p21 axis in acute myeloid leukemia. [Abstract]2025 Jul:188:118215. PMID: 40435838 -
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bioRxiv
Mitochondrial topoisomerase I (Top1MT) prevents the onset of metabolic dysfunction-associated steatohepatitis (MASH) in mice. [Abstract]2024 Sep 5:2024.09.05.611454. PMID: 39372760 -
Biomed Pharmacother
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway. [Abstract]2024 Aug:177:117008. PMID: 38901196 -
Biomed Pharmacother
Nicotinamide riboside attenuates myocardial ischemia-reperfusion injury via regulating SIRT3/SOD2 signaling pathway. [Abstract]2024 Jun:175:116689. PMID: 38703508 -
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Biomed Pharmacother
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway. [Abstract]2023 Dec 31:169:115937. PMID: 38007934 -
Heliyon
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice. [Abstract]2023 Jun 19;9(6):e17361. PMID: 37416635 -
Heliyon
2023 Feb 18;9(3):e13824. PMID: 36895361
Solvent & Solubility
DMSO : 100 mg/mL (131.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Fengjiao Jin, et al. The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility. Cancer Biol Med. 2019 Feb;16(1):38-54. [Content Brief]
[2]. Price OT, et al. Quantitative fluorescence of 5-FU-treated fetal rat limbs using confocal laser scanning microscopy and Lysotracker Red. Cytometry A. 2003;53(1):9-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3163 mL | 6.5815 mL | 13.1631 mL | 32.9077 mL |
| 5 mM | 0.2633 mL | 1.3163 mL | 2.6326 mL | 6.5815 mL | |
| 10 mM | 0.1316 mL | 0.6582 mL | 1.3163 mL | 3.2908 mL | |
| 15 mM | 0.0878 mL | 0.4388 mL | 0.8775 mL | 2.1938 mL | |
| 20 mM | 0.0658 mL | 0.3291 mL | 0.6582 mL | 1.6454 mL | |
| 25 mM | 0.0527 mL | 0.2633 mL | 0.5265 mL | 1.3163 mL | |
| 30 mM | 0.0439 mL | 0.2194 mL | 0.4388 mL | 1.0969 mL | |
| 40 mM | 0.0329 mL | 0.1645 mL | 0.3291 mL | 0.8227 mL | |
| 50 mM | 0.0263 mL | 0.1316 mL | 0.2633 mL | 0.6582 mL | |
| 60 mM | 0.0219 mL | 0.1097 mL | 0.2194 mL | 0.5485 mL | |
| 80 mM | 0.0165 mL | 0.0823 mL | 0.1645 mL | 0.4113 mL | |
| 100 mM | 0.0132 mL | 0.0658 mL | 0.1316 mL | 0.3291 mL |