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Cat. No.: HY-N21700

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Uralodin A

Uralodin A is a polycyclic polyprenylated acylphloroglucinol (PPAP). Uralodin A exerts cytotoxic activity through its inhibitory effects on tumor cells. Uralodin A can be used for cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 1189125-05-0
Formula: C₃₈H₅₀O₅
Molecular Weight:586.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Uralodin A Chemical Structure

CAS No.: 1189125-05-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	59.7 μM	Cytotoxic activity against human HepG2 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human HepG2 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990
SGC-7901	IC50	27.1 μM	Cytotoxic activity against human SGC7901 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human SGC7901 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990
HL-60	IC50	16.0 μM	Cytotoxic activity against human HL-60 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human HL-60 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990
K562	IC50	23.7 μM	Cytotoxic activity against human K562 tumor cells measured by MTT assay after continuous exposure for 48 h. Cytotoxic activity against human K562 tumor cells measured by MTT assay after continuous exposure for 48 h.	20087990

In Vitro

Uralodin A (compound 5) (0.064-40 μM; 48 h) exhibits moderate cytotoxic activity against HepG2, SGC7901, HL-60, and K562 cell lines, with IC₅₀ values all below 60 μM, and shows the strongest effect on HL-60 cells (16.0 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2, SGC7901, HL-60, K562
Concentration:

0.064, 0.32, 1.6, 8, 40 μM
Incubation Time:

48 h
Result:

Exhibited cytotoxic activity against all four tested tumor cell lines.
Had an IC50 value of 59.7 μM against HepG2 cells.
Had an IC50 value of 27.1 μM against SGC7901 cells.
Had an IC50 value of 16.0 μM against HL-60 cells.
Had an IC50 value of 23.7 μM against K562 cells.
Showed the highest potency against the HL-60 cell line.
Showed the lowest potency against the HepG2 cell line.

Chemical Information

CAS No. 1189125-05-0
Molecular Weight 586.80
Formula C₃₈H₅₀O₅
SMILES

O=C(C1=CC=CC=C1)[C@@]23[C@@](C)([C@H](C[C@]4(C(O[C@@H](C4)C(C)(O)C)=C(C3=O)C/C=C(C)\C)C2=O)C/C=C(C)\C)CC/C=C(C)/C
Structure Classification
- Terpenoids
- Other Terpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen XQ, et al. Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides. Chemistry & biodiversity. 2010 Jan;7(1):196-204.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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