Deoxycaesaldekarin C
Deoxycaesaldekarin C (Methyl vouacapenate) is a naturally occurring, orally active cassane furanoditerpene with antibacterial, antioxidant, antiplasmodial, and analgesic effects. Deoxycaesaldekarin C inhibits bacterial growth and lipid peroxidation, and scavenges free radicals. Deoxycaesaldekarin C exhibits weak antiplasmodial activity and shows analgesic activity in mouse in vivo models. Deoxycaesaldekarin C can be used in research related to pain, bacterial infections, and Plasmodium infections.
For research use only. We do not sell to patients.
- CAS No.: 4614-50-0
- Formula: C21H30O3
- Molecular Weight:330.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[2]|
Plasmodium |
In Vitro
Deoxycaesaldekarin C (compound 1) (12.5-200 μg/mL; 20 min) exhibits antioxidant activity, with DPPH radical scavenging IC50 = 97.4 μM and TBA lipid peroxidation inhibition IC50 = 134.8 μM[1].
Deoxycaesaldekarin C (1000-7.8 μg/mL; 24 h) exhibits antibacterial activity against a panel of bacteria, with the strongest effect against Bacillus subtilis (MIC = 47 μM)[1].
Deoxycaesaldekarin C (cpd 5) exhibits low to moderate antimalarial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) Plasmodium falciparum strains, with an IC50 of 25.67 μM against D6 and an IC50 of 30.33 μM against W2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Deoxycaesaldekarin C (100 mg/kg; i.p.; single administration) exhibits significant central antinociceptive activity in the hot-plate test[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice (20-25 g; either sex)[2]
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Dosage:100 mg/kg
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Administration:i.p.; single dose; 60 min before acetic acid
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Result:Reduced the number of writhing episodes induced by Acetic acid by 77.59% compared to control.
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Animal Model:Swiss albino mice (17-30 g; either sex)[2]
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Dosage:100 mg/kg
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Administration:i.p.; single dose
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Result:Showed significant central antinociceptive activity in the hot-plate test at 60 min relative to control.
Chemical Information
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CAS No. 4614-50-0
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Molecular Weight 330.46
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Formula C21H30O3
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])[C@](C)(CCC2)C(OC)=O)([H])[C@H](C4=C(OC=C4)C3)C
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Synonyms
Methyl vouacapenate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Aerobic Bacterial Batch Culture on Broth/Agar
Aerobic bacterial batch culture grows a closed inoculated population in broth or on agar without continuous medium replacement; growth readouts include turbidity/OD for total suspended biomass and colony-forming units for viable cells able to form colonies on agar. OD-based growth curves reflect light scattering by cells, but OD is instrument-, pathlength-, species-, cell-size-, and density-dependent, so OD should be calibrated or interpreted alongside viable counts when quantitative cell density is required.
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Ferroptosis Solutions
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by lethal lipid peroxidation and sensitivity to suppression by iron chelators or lipophilic radical-trapping antioxidants. The core pathway links cystine uptake through system Xc−, glutathione availability, GPX4-dependent detoxification of phospholipid hydroperoxides, iron-dependent oxidative reactions, and polyunsaturated-phospholipid metabolism into a cell-death program that is biochemically and morphologically distinct from apoptosis, necrosis, and autophagy. The ferroptosis pathway is experimentally linked to phenotype through chemical and genetic perturbation. Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death. ACSL4 and oxidizable arachidonoyl- or adrenoyl-containing phosphatidylethanolamines shape ferroptosis sensitivity by con
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deoxycaesaldekarin C Related Classifications
HY-N21639 Related Classifications
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