DHODH-IN-14
Based on 1 Customer Validation
DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 1364791-93-4
- Formula: C15H7F4N3O3
- Molecular Weight:353.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
IC50: 0.49 μM (Rat liver DHODH)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
59.7 μM
Compound: 2
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Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method
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[PMID: 28235702] |
DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold with fluoro substituents. Moving to derivatives DHODH-IN-14, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-14 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1364791-93-4
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Appearance Solid
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Molecular Weight 353.23
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Formula C15H7F4N3O3
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Color White to off-white
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SMILES
O=C(C1=NONC1=O)NC2=C(F)C(F)=C(C3=CC=CC=C3)C(F)=C2F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 125 mg/mL (353.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8310 mL | 14.1551 mL | 28.3102 mL | 70.7754 mL |
| 5 mM | 0.5662 mL | 2.8310 mL | 5.6620 mL | 14.1551 mL | |
| 10 mM | 0.2831 mL | 1.4155 mL | 2.8310 mL | 7.0775 mL | |
| 15 mM | 0.1887 mL | 0.9437 mL | 1.8873 mL | 4.7184 mL | |
| 20 mM | 0.1416 mL | 0.7078 mL | 1.4155 mL | 3.5388 mL | |
| 25 mM | 0.1132 mL | 0.5662 mL | 1.1324 mL | 2.8310 mL | |
| 30 mM | 0.0944 mL | 0.4718 mL | 0.9437 mL | 2.3592 mL | |
| 40 mM | 0.0708 mL | 0.3539 mL | 0.7078 mL | 1.7694 mL | |
| 50 mM | 0.0566 mL | 0.2831 mL | 0.5662 mL | 1.4155 mL | |
| 60 mM | 0.0472 mL | 0.2359 mL | 0.4718 mL | 1.1796 mL | |
| 80 mM | 0.0354 mL | 0.1769 mL | 0.3539 mL | 0.8847 mL | |
| 100 mM | 0.0283 mL | 0.1416 mL | 0.2831 mL | 0.7078 mL |
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