1. Anti-infection
    Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Influenza Virus
    Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-9

DHODH-IN-9 

Cat. No.: HY-135667
Handling Instructions

DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4.

For research use only. We do not sell to patients.

DHODH-IN-9 Chemical Structure

DHODH-IN-9 Chemical Structure

CAS No. : 1644156-41-1

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Description

DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].

IC50 & Target

pMIC50: 7.4 (DHODH)[1]

In Vitro

DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue[1].

Molecular Weight

366.43

Formula

C₂₁H₂₃FN₄O

CAS No.

1644156-41-1

SMILES

CC(C)OC1=NN(C2=NC=C(C3CC3)C=N2)C(C)=C1CC4=CC=CC=C4F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHODH-IN-9Influenza VirusDihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHhumandihydroorotatedehydrogenaseantiviralmeaslesazine-bearingInhibitorinhibitorinhibit

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