Dimebutic acid sodium
Dimebutic acid sodium is an orally active short-chain fatty acid. Dimebutic acid sodium stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid sodium prolongs red blood cell survival. Dimebutic acid sodium exhibits toxicity in rats. Dimebutic acid sodium can be used in the study of β-thalassemia and sickle cell disease.
For research use only. We do not sell to patients.
- CAS No.: 3934-02-9
- Formula: C6H11NaO2
- Molecular Weight:138.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (male: 200-260 g, female: 160-220 g)[2]
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Dosage:200 mg/kg, 600 mg/kg, 1000 mg/kg
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Administration:Oral gavage (p.o.)
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Result:Did not cause mortality in any dose group.
Showed ataxia for females, had rough coat and thin appearance for males (at 1000 mg/kg).
Showed frequent functional observational battery (FOB) deficits in females, including decreased body tone, rectal temperature, etc.
Decreased RBC, HGB, HCT and increased reticulocytes at high doses.
Increased liver and kidney weights at 1000 mg/kg.
Chemical Information
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CAS No. 3934-02-9
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Molecular Weight 138.14
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Formula C6H11NaO2
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SMILES
CCC(C)(C(O[Na])=O)C
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Synonyms
NSC-16045 sodium; NSC-741804 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Parise RA, et al. Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):168-74. [Content Brief]
[2]. Terse PS, et al. Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats. Toxicol Pathol. 2011 Jun;39(4):614-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dimebutic acid sodium Related Classifications
HY-W015881A Related Classifications
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