2-Piperidone
Based on 1 Customer Validation
2-Piperidone is an endogenous metabolite. 2-Piperidone is the biomarker for the activity of CYP2E1.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 675-20-7
- Formula: C5H9NO
- Molecular Weight:99.13
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Natural Product Library
HY-L021
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Human Endogenous Metabolite Compound Library
HY-L030
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Orally Active Compound Library
HY-L061
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Food-Sourced Compound Library
HY-L094
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Human Metabolite Library
HY-L123
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Heterocyclic Compound Library
HY-L138
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Animal-Sourced Natural Product Library
HY-L157
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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RO5 Drug-like Natural Product Library
HY-L200
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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Mass Spectrometry Human Endogenous Metabolite Library
HY-L207
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Mass Spectrometry Human Metabolite Library
HY-L215
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Mass Spectrometry Natural Product Library
HY-L262
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Drug Fragment Library
HY-L904
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CCl4 (HY-Y0298)-induced hepatotoxicity in Wistar rats models[2]
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Dosage:0.25-0.5 mg/kg
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Administration:po, twice a day for 28 days
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Result:Reduced the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum.
Promoted the regeneration of hepatocytes.
Chemical Information
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CAS No. 675-20-7
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Appearance <38°C Solid,>40°C Liquid
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Molecular Weight 99.13
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Formula C5H9NO
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Color Off-white to light yellow
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SMILES
O=C1NCCCC1
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Synonyms
δ-Valerolactam
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (1008.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (1008.75 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (25.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (25.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 10.0875 mL | 50.4373 mL | 100.8746 mL | 252.1864 mL |
| 5 mM | 2.0175 mL | 10.0875 mL | 20.1749 mL | 50.4373 mL | |
| 10 mM | 1.0087 mL | 5.0437 mL | 10.0875 mL | 25.2186 mL | |
| 15 mM | 0.6725 mL | 3.3625 mL | 6.7250 mL | 16.8124 mL | |
| 20 mM | 0.5044 mL | 2.5219 mL | 5.0437 mL | 12.6093 mL | |
| 25 mM | 0.4035 mL | 2.0175 mL | 4.0350 mL | 10.0875 mL | |
| 30 mM | 0.3362 mL | 1.6812 mL | 3.3625 mL | 8.4062 mL | |
| 40 mM | 0.2522 mL | 1.2609 mL | 2.5219 mL | 6.3047 mL | |
| 50 mM | 0.2017 mL | 1.0087 mL | 2.0175 mL | 5.0437 mL | |
| 60 mM | 0.1681 mL | 0.8406 mL | 1.6812 mL | 4.2031 mL | |
| 80 mM | 0.1261 mL | 0.6305 mL | 1.2609 mL | 3.1523 mL | |
| 100 mM | 0.1009 mL | 0.5044 mL | 1.0087 mL | 2.5219 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Piperidone Related Classifications
HY-W042193 Related Classifications
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