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Cat. No.: HY-187615

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AM4299 A

AM4299 A is a thiol protease inhibitor with IC₅₀ values of 73, 390 and 88 nM against Cathepsin B, Cathepsin L and Papain, respectively. AM4299 A shows low toxicity and favorable biosafety in mice. AM4299 A can be used in studies related to osteoporosis and parasitic diseases.

For research use only. We do not sell to patients.

CAS No.: 160825-48-9
Formula: C₁₅H₂₆N₂O₆
Molecular Weight:330.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AM4299 A Chemical Structure

CAS No.: 160825-48-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Cathepsin C

73 nM (IC₅₀)

cathepsin L

390 nM (IC₅₀)

papain

88 nM (IC₅₀)

All Cathepsin Isoforms :

In Vitro

AM4299 A specifically inhibits purified bovine spleen cathepsin B (IC₅₀ = 7.3 × 10^-8 M), human kidney cathepsin L (IC₅₀ = 3.9 × 10^-7 M), and Carica papaya papain (IC₅₀ = 8.8 × 10^-8 M), with no activity against bovine pancreas trypsin or α-chymotrypsin at concentrations up to 8.0 × 10^-5 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

AM4299 A (intravenous injection; 200 mg/kg) causes no mortality and exhibits low acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 160825-48-9
Molecular Weight 330.38
Formula C₁₅H₂₆N₂O₆
SMILES

C(N[C@H](C(NCCCCCO)=O)CC(C)C)(=O)C1C(C(O)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Morishita A, et al. AM4299 A and B, novel thiol protease inhibitors[J]. The Journal of Antibiotics, 1994, 47(9): 1065-1068.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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