CB096
Based on 1 Customer Validation
CB096 is an r(G4C2)exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2)exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD).
For research use only. We do not sell to patients.
- Purity : 98.72%
- CAS No.: 108883-90-5
- Formula: C14H11N3O4
- Molecular Weight:285.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
r (G4C2)exp RNA refers to a neurotoxic RNA molecule transcribed from the abnormally expanded hexanucleotide repeat sequence (GGGGCC, i.e., G4C2) in the C9orf72 gene[1].
CB096 (100 μM; EC50) potently binds the r (G4C2)8 hairpin RNA, with an EC50 value of 33 μM as determined by the TO1 dye displacement assay[1].
CB096 (25 μM; 24 h) reverses approximately 75% of nucleocytoplasmic transport dysfunction induced by the expression of r (G4C2)66 in HEK293T cells, with its mechanism of action being the inhibition of RAN translation without affecting canonical translation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 108883-90-5
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Appearance Solid
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Molecular Weight 285.25
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Formula C14H11N3O4
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Color Yellow to orange
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SMILES
OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (175.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ursu A, et al. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020;15(12):3112-3123. [Content Brief]
[2]. Ursu A, et al. A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks. ACS Chem Neurosci. 2021;12(21):4076-4089. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5057 mL | 17.5285 mL | 35.0570 mL | 87.6424 mL |
| 5 mM | 0.7011 mL | 3.5057 mL | 7.0114 mL | 17.5285 mL | |
| 10 mM | 0.3506 mL | 1.7528 mL | 3.5057 mL | 8.7642 mL | |
| 15 mM | 0.2337 mL | 1.1686 mL | 2.3371 mL | 5.8428 mL | |
| 20 mM | 0.1753 mL | 0.8764 mL | 1.7528 mL | 4.3821 mL | |
| 25 mM | 0.1402 mL | 0.7011 mL | 1.4023 mL | 3.5057 mL | |
| 30 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9214 mL | |
| 40 mM | 0.0876 mL | 0.4382 mL | 0.8764 mL | 2.1911 mL | |
| 50 mM | 0.0701 mL | 0.3506 mL | 0.7011 mL | 1.7528 mL | |
| 60 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.4607 mL | |
| 80 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0955 mL | |
| 100 mM | 0.0351 mL | 0.1753 mL | 0.3506 mL | 0.8764 mL |
CB096 Related Classifications
HY-W141374 Related Classifications
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