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Domusiran

(Synonyms: ALY-101)

Domusiran (ALY-101) is a Jak-1 inhibitor.

For research use only. We do not sell to patients.

  • CAS No.: 3077456-78-8
  • Formula: C422H547F15N137O250P39S13
  • Molecular Weight:13448.40
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Domusiran Chemical Structure
    Domusiran Chemical Structure
CAS No.: 3077456-78-8
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Use of MCE Products

All JAK Isoforms

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  • Domusiran Chemical Structure
    Domusiran Chemical Structure RNA, ([(5E)-5′,6′-dideoxy-6′-phosphono-β-D-ribo-hex-5-enofurano]Um-sp-(2′-deoxy-2′-fluoro)C-sp-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)U-sp-Am-sp-(2′-deoxy-2′-fluoro)C-sp-Um-sp-Um-sp-Cm-sp-(2′-deoxy-2′-fluoro)A-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)G-Gm-(2′-deoxy-2′-fluoro)A-Am-Um-Cm-(2′-deoxy-2′-fluoro)U-sp-Gm-sp-Am-dT-dT) 3′-[2-(hydroxymethyl)-6-[(1-oxodocosyl)amino]hexyl hydrogen phosphate] (1:1)
    1/16
  • RNA, ([(5E)-5′,6′-dideoxy-6′-phosphono-β-D-ribo-hex-5-enofurano]Um-sp-(2′-deoxy-2′-fluoro)C-sp-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)U-sp-Am-sp-(2′-deoxy-2′-fluoro)C-sp-Um-sp-Um-sp-Cm-sp-(2′-deoxy-2′-fluoro)A-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)G-Gm-(2′-deoxy-2′-fluoro)A-Am-Um-Cm-(2′-deoxy-2′-fluoro)U-sp-Gm-sp-Am-dT-dT) 3′-[2-(hydroxymethyl)-6-[(1-oxodocosyl)amino]hexyl hydrogen phosphate] (1:1)