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PSMC6 - proteasome 26S subunit, ATPase 6 Gene

Also Known as p42; RPT5; SUG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5706

About PSMC6

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,707,200-52,728,590 (from NCBI)

This gene has 18 transcripts (splice variants), 226 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 15.2), brain (RPKM 15.0) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

PSMC6 Products (2)

mRNA	Protein	Name
NM_001366414.2	NP_001353343.1	26S proteasome regulatory subunit 10B isoform 2
NM_002806.5	NP_002797.4	26S proteasome regulatory subunit 10B isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10419517	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	9464850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMC6 Protein Structure

AAA

0
100
200
300
389 a.a.

Protein Preferred Names	Protein Names
26S proteasome regulatory subunit 10B	26S proteasome AAA-ATPase subunit RPT4

PSMC6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMC6	P62333	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	PSMC6	P62333	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	PSMC6	P62333	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	PSMC6	P62333	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Prey Pooling	25416956
Intra	PSMC6	P62333	CCDC146	Homo sapiens	Q8IYE0-2	Validated Y2H	25416956
Intra	PSMC6	P62333	PSME4	Homo sapiens	Q14997	Anti Tag CoIP	35271311
Intra	PSMC6	P62333	PSME4	Homo sapiens	Q14997	Anti Bait CoIP	18845680
Intra	PSMC6	P62333	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	PSMC6	P62333	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PSMC6	P62333	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PSMC6	P62333	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PSMC6	P62333	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PSMC6	P62333	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PSMC6	P62333	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PSMC6	P62333	PSMC1	Homo sapiens	P62191	3D-EM	29636472
Intra	PSMC6	P62333	PSMC1	Homo sapiens	P62191	Solution Sedimentation	19490896
Intra	PSMC6	P62333	PSMC1	Homo sapiens	P62191	3D-EM-Single	27342858
Intra	PSMC6	P62333	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	19490896
Intra	PSMC6	P62333	PSMC1	Homo sapiens	P62191	Anti Tag CoIP	35271311
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	Anti Tag CoIP	19490896
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	3D-EM-Single	27342858
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	Y2H Array	32296183
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	Solution Sedimentation	19490896
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	3D-EM	29636472
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	Y2H Prey Pooling	25416956
Intra	PSMC6	P62333	PSMC3	Homo sapiens	P17980	Y2H Prey Pooling	32296183
Intra	PSMC6	P62333	PSMC5	Homo sapiens	P62195	Solution Sedimentation	19490896
Intra	PSMC6	P62333	PSMC5	Homo sapiens	P62195	3D-EM-Single	27342858
Intra	PSMC6	P62333	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	19490896
Intra	PSMC6	P62333	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	35271311
Intra	PSMC6	P62333	PSMC5	Homo sapiens	P62195	3D-EM	29636472
Intra	PSMC6	P62333	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	PSMC6	P62333	PSMD4	Homo sapiens	P55036	3D-EM	29636472
Intra	PSMC6	P62333	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	35271311
Intra	PSMC6	P62333	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	PSMC6	P62333	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PSMC6	P62333	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PSMC6	P62333	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PSMC6	P62333	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	PSMC6	P62333	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	PSMC6	P62333	PSMC4	Homo sapiens	P43686	3D-EM	29636472
Intra	PSMC6	P62333	PSMC4	Homo sapiens	P43686	Solution Sedimentation	19490896
Intra	PSMC6	P62333	PSMC4	Homo sapiens	P43686	3D-EM-Single	27342858
Intra	PSMC6	P62333	PSMC4	Homo sapiens	P43686	Anti Tag CoIP	19490896
Intra	PSMC6	P62333	PSMC4	Homo sapiens	P43686	Anti Tag CoIP	35271311
Intra	PSMC6	P62333	CYB5R2	Homo sapiens	Q6BCY4	Validated Y2H	25416956
Intra	PSMC6	P62333	CYB5R2	Homo sapiens	Q6BCY4	Y2H Array	25416956
Intra	PSMC6	P62333	CYB5R2	Homo sapiens	Q6BCY4	Y2H Prey Pooling	25416956
Intra	PSMC6	P62333	C1orf216	Homo sapiens	Q8TAB5	Y2H Pooling	16189514
Intra	PSMC6	P62333	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	PSMC6	P62333	PSMD9	Homo sapiens	O00233	Y2H Array	32296183
Intra	PSMC6	P62333	PSMD9	Homo sapiens	O00233	Y2H Pooling	16189514
Intra	PSMC6	P62333	PSMD9	Homo sapiens	O00233	Y2H Array	31515488
Intra	PSMC6	P62333	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	32296183
Intra	PSMC6	P62333	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	35271311
Intra	PSMC6	P62333	PSMD9	Homo sapiens	O00233	Y2H Array	25416956
Cross	PSMC6	P62333	N	Human SARS coronavirus	P59595	Confocal	20478047
Intra	PSMC6	P62333	CRK	Homo sapiens	P46108	Y2H Array	32296183
Intra	PSMC6	P62333	CRK	Homo sapiens	P46108	Y2H Prey Pooling	32296183
Intra	PSMC6	P62333	CRKL	Homo sapiens	P46109	Y2H Prey Pooling	32296183
Intra	PSMC6	P62333	CRKL	Homo sapiens	P46109	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Ehrlichiosis	Human Ehrlichiosis He Hey
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11316	PSMC6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMC6	RGD	RGD:1308825
Mus musculus	PSMC6	MGD	MGI:1914339
Felis catus	PSMC6	VGNC	VGNC:69117
Bos taurus	PSMC6	VGNC	VGNC:33460
Others	PSMC6	NCBI