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CD74 - CD74 molecule Gene

Also Known as II; p33; CLIP; DHLAG; HLADG; Ia-GAMMA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 972

About CD74

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,401,639-150,412,910 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues and is associated with 57 phenotypes. Broad expression in spleen (RPKM 1835.3), lymph node (RPKM 1421.7) and 24 other tissues.

Summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

CD74 Products (5)

mRNA	Protein	Name
NM_001025158.3	NP_001020329.1	HLA class II histocompatibility antigen gamma chain isoform c
NM_001025159.3	NP_001020330.1	HLA class II histocompatibility antigen gamma chain isoform a
NM_001364083.3	NP_001351012.1	HLA class II histocompatibility antigen gamma chain isoform d
NM_001364084.3	NP_001351013.1	HLA class II histocompatibility antigen gamma chain isoform e
NM_004355.4	NP_004346.1	HLA class II histocompatibility antigen gamma chain isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CD4 receptor binding	IPI IPI: Inferred from physical interaction	24942581	GOA
enables MHC class II protein binding, via antigen binding groove	IDA IDA: Inferred from direct assay	7477400	GOA
enables MHC class II protein complex binding	IDA IDA: Inferred from direct assay	1448172	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	19849849	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	17567581	GOA
enables cytokine receptor activity	IDA IDA: Inferred from direct assay	17045821	GOA
enables macrophage migration inhibitory factor binding	IPI IPI: Inferred from physical interaction	17045821	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17357109	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	7477400	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	17045821	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12782713	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20198449	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17045821	GOA
involved in negative regulation of peptide secretion	IDA IDA: Inferred from direct assay	19849849	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	32855215	GOA
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12782713	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17045821	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	12782713	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	19423618	GOA
involved in positive regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12782713	GOA
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12782713	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19423618	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	24569872	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24569872	GOA
involved in positive regulation of kinase activity	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of macrophage migration inhibitory factor signaling pathway	IMP IMP: Inferred from mutant phenotype	19665027	GOA
involved in positive regulation of monocyte differentiation	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	24569872	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	24942581	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	24942581	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	12782713	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	32855215	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	17045821	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22952837	GOA
part of macrophage migration inhibitory factor receptor complex	IDA IDA: Inferred from direct assay	17045821	GOA
located in membrane	IDA IDA: Inferred from direct assay	12782713	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19423618	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19665027	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19665027	GOA
located in vacuole	IDA IDA: Inferred from direct assay	19849849	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD74 Protein Structure

MHC2-interact

MHCassoc_trimer

Thyroglobulin_1

0
100
200
296 a.a.

Protein Preferred Names	Protein Names
HLA class II histocompatibility antigen gamma chain	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

CD74 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD74	P04233	CXCR2	Homo sapiens	P25025	Anti Tag CoIP	17435771
Intra	CD74	P04233	CXCR2	Homo sapiens	P25025	Anti Bait CoIP	17435771
Intra	CD74	P04233	KPNB1	Homo sapiens	Q14974	Pull Down	30833792
Intra	CD74	P04233	EIF3E	Homo sapiens	P60228	Pull Down	30833792
Intra	CD74	P04233	CXCR4	Homo sapiens	P61073	Anti Tag CoIP	19665027
Intra	CD74	P04233	CXCR4	Homo sapiens	P61073	Anti Bait CoIP	19665027
Intra	CD74	P04233	CD44	Homo sapiens	P16070	Confocal	29190904
Cross	CD74	P04233	dnaK	Escherichia coli	P0A6Y8	Solid Phase Assay	17357109

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD74 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72931	CD74 Protein, Human (HEK293, His)	NP_004346.1 (Q73-M232)	≥ 95%, as determined by Bis-Tris PAGE.

CD74 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81537	CD74 Antibody (YA1282)	IHC-P	Human
HY-P81537A	CD74 Antibody (YA1282)(PBS only)	IHC-P	Human
HY-P83941	CD74 Antibody (YA3638)	WB, ICC/IF, FC, ELISA	Human
HY-P83941A	CD74 Antibody (YA3638)(PBS only)	WB, ICC/IF, FC, ELISA	Human
HY-P85007	CD74 Antibody (YA4699)	ELISA, FC	Human
HY-P85898	CD74 Antibody (YA5590)	IHC-P, WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Mucinous Lung Adenocarcinoma
Mucinous Adenocarcinoma	Mucin-Producing Adenocarcinoma Mucin-Secreting Adenocarcinoma Mucin-Secreting Carcinoma Mucous Carcinoma Pseudomyxoma Peritonei With Unknown Primary Site Adenocarcinoma, Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99731	Milatuzumab	Inhibitor	99.39%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1826	CLIP (86-100)		98.39%	Unkown
HY-P11303	PADRE peptide	Ligand	98.28%	Unkown
HY-103333	Arvanil	Inhibitor	99.1%	Unkown
HY-N2245	Schisandrone	Inhibitor	99.78%	Unkown
HY-107101	(5R)-5-Hydroxytriptolide	Inhibitor	99.67%	Unkown
HY-128356	SPL-410	Inhibitor	99.38%	Unkown
HY-D3334	PE-CF594		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990728	Bezetabart	Inhibitor	99.00%	Unkown
HY-P991837	Anti-HLA-DP Antibody (B7/21)	Inhibitor	/	Unkown
HY-P991844	Anti-HLA-DQ Antibody (1a3)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD74	VGNC	VGNC:38972
Bos taurus	CD74	VGNC	VGNC:52227
Macaca mulatta	CD74	VGNC	VGNC:70779
Rattus norvegicus	CD74	RGD	RGD:2313
Felis catus	CD74	VGNC	VGNC:60638
Mus musculus	CD74	MGD	MGI:96534
Others	CD74	NCBI