GRL-8234
GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM). GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD).
For research use only. We do not sell to patients.
- CAS No.: 913071-81-5
- Formula: C36H42N4O6S
- Molecular Weight:658.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.001 μM
Compound: 24, GRL-8234
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Inhibition of memapsin 2 expressed in CHO cells
Inhibition of memapsin 2 expressed in CHO cells
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[PMID: 18180160] |
Chemical Information
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CAS No. 913071-81-5
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Molecular Weight 658.81
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Formula C36H42N4O6S
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SMILES
O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC(OC)=CC=C3)O)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GRL-8234 Related Classifications
HY-10104 Related Classifications
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